Molekulargenetik der humanen Hypertonie

Identification Of Genetic Variants In AGT Gene With Association With Increased Blood Pressure And The Risk Of Hypertension.

“…The nutritional status in people also influences the blood supply to adipose tissue and affects vascular resistance and blood pressure in obese individuals. The concentration of plasma AGT strongly correlated with blood pressure during weight loss (Luft, 1997).…”

“…Direct immunoassays, using against AGT the monoclonal and polyclonal antibodies that estimate both its inactive C-terminal part and intact AGT, des (Ang I) AGT, have also been developed. In the liver, which contains mainly enzymes capable of metabolizing Ang I, it doing this method precisely quantifies AGT in tissues making a problematic interpretation of the enzymatic assay (Luft, 1997).…”

“…The evaluated studies are many which appear the relative risk of cardiovascular diseases conferred by the renin-angiotensin system and its gene variants (Cambien et al, 1992). One reported in the "Etude Cas-Te'moin de l'Infarctus du Myocarde" (ECTIM) mention the link myocardial infarction in Caucasian patients and variants of the ACE gene, which considered at little risk of cardiovascular diseases according to their body mass index and lipid profile (Luft, 1997).…”

“…Whereas they found the M174 allele in carriers individuals were more often receiving antihypertensive treatment, a more significant proportion of them required several drugs. Three studies have shown a link of the M235T AGT allele with coronary heart disease (Luft, 1997).…”

“…The more complications of insulin-dependent diabetes mellitus (IDDM) are Degenerative retinopathy and nephropathy. These complications influenced by several factors such as blood glucose control, the duration time of IDDM, and genetic factors (Luft, 1997). In diabetic nephropathy, the genes of the renin-angiotensin system, in particular ACE, may be implicated because high glomerular concentrations of angiotensin II can support glomerular hypertension and contribute to renal deterioration (Marre M, 1996).…”