A novel technique, called augmented whole-body scanning via magnifying PET (AWSM-PET), that improves the sensitivity and lesion detectability of a PET scanner for whole-body imaging is proposed and evaluated. A Siemens Biograph Vision PET/CT scanner equipped with one or two high-resolution panel-detectors was simulated to study the effectiveness of AWSM-PET Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/ publications/rights/index.html for more information.