Molecules at Play in Cancer

Abstract

Despite its wide range of incidence, cancer can spontaneously occur in any part of the body and invade regions other than the originally affected tissue [...]

Advanced Molecular Solutions for Cancer Therapy—The Good, the Bad, and the Ugly of the Biomarker Paradigm

“…Identifying the most effective actionable molecules whose “smart” manipulation might selectively kill/slow down/stop the proliferation of cancer cells, with few side effects on the normal cells of the tissue, was for decades the single major objective of countless investigators. This Special Issue (SI), a continuation of the previous Current Issues in Molecular Biology SI “Molecules at Play in Cancer” [ 1 ], aimed to present the latest developments in the molecular solutions for cancer therapy, and the ways of personalizing the treatment to the individual characteristics of the patient. The authors have contributed their best efforts, either by performing accurate experiments, reanalyzing publicly accessible genomic datasets (including The Cancer Genome Atlas (TCGA) [ 2 ]), or writing comprehensive reviews of the literature.…”