Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing

Parlak, Onur; Keene, Scott T.; Marais, Andrew; Curto, Vincenzo F.; Salleo, Alberto

doi:10.1126/sciadv.aar2904

Cited by 466 publications

(434 citation statements)

References 40 publications

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“…It is noteworthy that the performance of colorimetric mode ASV is primarily determined by the chromogenic reagent which could be improved by the development of advanced colorimetric chemistries. [ 27,41 ]…”

Section: Resultsmentioning

confidence: 99%

A Bioinspired Wireless Epidermal Photoreceptor for Artificial Skin Vision

Zhang

Tao

2020

Adv Funct Materials

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Skin vision can be found in many invertebrates, such as earthworms, jellyfish, and octopuses using light-sensitive rod cells in the skin. It enables optical perception and colorimetric responses, providing intriguing capabilities that human skin does not have. A bioinspired wireless, battery-free, artificial skin vision (ASV) device consisting of flexible optical and optoelectronic components which essentially mimic the hierarchical structures and biological functions of rod cells in a skin-like configuration for light sensing and signal processing is developed. The ASV device can collect sweat with integrated microfluidic channels and allow real-time measurement of on-skin fluids by monitoring the intrinsic optical properties via a customizable microprism light filter. The device also shows sensitive colorimetric responses to input stimulus at chosen detection wavelengths and demonstrates a capacity for in situ quantitative analysis of biomarkers in sweat through alternative colorimetric light filters. Multiple ASVs together create a body area network with a collection of wireless sensors that can work in parallel to acquire multidimensional human physiological signals and predict fitness variations using a specified deep learning neural network. The system has potential applications in biomimetic engineering, physiological monitoring, and intelligent personalized diagnostics.

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Section: Resultsmentioning

confidence: 99%

A Bioinspired Wireless Epidermal Photoreceptor for Artificial Skin Vision

Zhang

Tao

2020

Adv Funct Materials

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“…Device Fabrication : The SEBS substrate with printed contacts was prepared by following the procedure that was published in a previous study . After printing the electrodes, the first layer of PEDOT:PSS was spin‐coated.…”

Section: Methodsmentioning

confidence: 99%

“…As a final step, double‐ and single‐sided medical‐grade tapes were integrated with multiplexed ion‐selective membrane‐based sensor surface after laser patterning to provide direct sampling of sweat. These laser‐patterned microfluidic channels for sampling of sweat to the sensor interface were prepared and integrated to the device as described in a previous study . Briefly, a femtosecond laser (500 mW, 808 nm, 1 kHz, Spectra‐Physics) was focused to a spot size of 5 µm diameter on the surface of the polyimide medical tape for ≈2 s to generate microcapillary channels.…”

Section: Methodsmentioning

confidence: 99%

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

Keene

Fogarty

Cooke

et al. 2019

Adv Healthcare Materials

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140

115

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Wearable health monitoring has garnered considerable interest from the healthcare industry as an evolutionary alternative to standard practices with the ability to provide rapid, off‐site diagnosis and patient‐monitoring. In particular, sweat‐based wearable biosensors offer a noninvasive route to continuously monitor a variety of biomarkers for a range of physiological conditions. Both the accessibility and wealth of information of sweat make it an ideal target for noninvasive devices that can aid in early diagnosis of disease or to monitor athletic performance. Here, the integration of ammonium (NH4+) and calcium (Ca2+) ion‐selective membranes with a poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)‐based (PEDOT:PSS) organic electrochemical transistor (OECT) for multiplexed sensing of NH4+ and Ca2+ in sweat with high sensitivity and selectivity is reported for the first time. The presented wearable sweat sensor is designed by combining a flexible and stretchable styrene‐ethylene‐butene‐styrene substrate with a laser‐patterned microcapillary channel array for direct sweat acquisition and delivery to the ion‐selective OECT. The resulting dermal sensor exhibits a wide working range between 0.01 × 10−3 and 100 × 10−3 m, well within the physiological levels of NH4+ and Ca2+ in sweat. The integrated devices are successfully implemented with both ex situ measurements and on human subjects with real‐time analysis using a wearable sensor assembly.

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“…These unique properties of PEDOT:PSS have enabled the development of numerous advanced organic electronic devices including solar cells, light‐emitting diodes, transistors, memristors, and artificial synapses for neuromorphic computing . Recently, with the rising research trend in flexible electronics, which have offered unprecedented opportunities in revolutionizing our understanding of electronic devices, PEDOT:PSS has extended its important role in developing various flexible organic electronic devices such as organic electrochemical transistors (OECTs), an emerging tool for biosensing . However, directly manipulating and patterning PEDOT:PSS thin films on flexible substrates remain challenging because of difficulties in obtaining uniform and continuous films on soft substrates such as plastics and elastomers due to their hydrophobic nature .…”

Section: Introductionmentioning

confidence: 99%

Hydrogel‐Enabled Transfer‐Printing of Conducting Polymer Films for Soft Organic Bioelectronics

Zhang

Ling

Chen

et al. 2019

Adv Funct Materials

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The use of conducting polymers such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) for the development of soft organic bioelectronic devices, such as organic electrochemical transistors (OECTs), is rapidly increasing. However, directly manipulating conducting polymer thin films on soft substrates remains challenging, which hinders the development of conformable organic bioelectronic devices. A facile transfer-printing of conducting polymer thin films from conventional rigid substrates to flexible substrates offers an alternative solution. In this work, it is reported that PEDOT:PSS thin films on glass substrates, once mixed with surfactants, can be delaminated with hydrogels and thereafter be transferred to soft substrates without any further treatments. The proposed method allows easy, fast, and reliable transferring of patterned PEDOT:PSS thin films from glass substrates onto various soft substrates, facilitating their application in soft organic bioelectronics. By taking advantage of this method, skin-attachable tattoo-OECTs are demonstrated, relevant for conformable, imperceptible, and wearable organic biosensing.

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Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing

Abstract: A new wearable nanoporous organic electrochemical device used as a medical diagnostics tool for noninvasive hormone sensing.

Cited by 466 publications

References 40 publications

A Bioinspired Wireless Epidermal Photoreceptor for Artificial Skin Vision

A Bioinspired Wireless Epidermal Photoreceptor for Artificial Skin Vision

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

Hydrogel‐Enabled Transfer‐Printing of Conducting Polymer Films for Soft Organic Bioelectronics

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