Molecularly Imprinted Polymers with Strong Carboxypeptidase A‐Like Activity: Combination of an Amidinium Function with a Zinc‐Ion Binding Site in Transition‐State Imprinted Cavities

Liu, Junqiu; Wulff, Günter

doi:10.1002/anie.200352770

Cited by 131 publications

(56 citation statements)

References 27 publications

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“…2). Wulff's group [59][60][61] and Resmini's group [62,63] have pioneered in this area. Several polymers mimicking the hydrolytic activity of some enzymes have been synthesized using the TSA approximation, which stabilized the intermediate state and lowered the activation energy.…”

Section: Mip-based Quartz Crystal Microbalance Bioassaysmentioning

confidence: 99%

Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation

Liu

Huang

et al. 2015

Molecularly Imprinted Polymers in Biotechnology

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In the past five years, significant progress has been made in preparation of various molecularly imprinted polymer (MIP)-based materials for applications in bioassays and biotransformation. This chapter reviews the important advances in these two fields. The first part mainly focuses on the development of various MIP-based bioassays that convert the rebinding of template to the imprinted cavities into measurable luminescent signals, including fluorescence, phosphorescence, Raman scattering, diffraction, and the like. In addition, MIP-based bioassays that are measured by surface plasmon resonance or quartz crystal microbalance are also discussed. In the following part, representative biotransformation reactions that make use of MIPs are summarized. In the last part of this chapter, some remaining challenges are briefly discussed for further development of the two fields.

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Section: Mip-based Quartz Crystal Microbalance Bioassaysmentioning

confidence: 99%

Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation

Liu

Huang

et al. 2015

Molecularly Imprinted Polymers in Biotechnology

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“…Molecularly imprinted techniques have been shown to be an efficient way of providing functionalized materials and recognizing the specific molecules in a mixture of related compounds [15][16][17]. As reported by Li et al [18], for example, the use of molecularly imprinted polymer (MIP) improved the selectivity of the fluorescent determination of 2,4,6-trinitrotoluene.…”

Section: Introductionmentioning

confidence: 94%

Electrochemical Determination of Tetracycline Using Molecularly Imprinted Polymer Modified Carbon Nanotube‐Gold Nanoparticles Electrode

et al. 2011

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This paper reports the use of a tetracycline (TC) sensor constructed from a combination of molecularly imprinted polymer (MIP) and gold nanoparticles modified multiwall carbon nanotubes (MWNTs-GNPs). The results demonstrated that the amount of recognition sites in the polymer was significantly increased and the electron transfer ability of the sensor was improved. The relationship between the peak current and the TC concentration was linear in the range from 0.1 to 40 mg L À1 , and the detection limit was 0.04 mg L À1 (S/N = 3). The peak current to TC was 4.3, 6.2 and 6.8 times larger than that of oxytetracycline, chloramphenicol and nafcillin, respectively. Thus, the combination of MIP and MWNTs-GNPs provides a sensitive and selective electrochemical detection method for tetracycline.

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“…The application of metals with the molecular imprinting approach has yet to be fully exploited, especially in the context of developing biomimetic catalysts, although from the examples described later it is clear that there is still a lot of potential. Liu and Wulff [20] reported the synthesis of imprinted polymers mimicking the activity of carboxypeptidase A, by using an amidinium functional monomer and a trialkylamine unit coordinating a Zn(II) atom that was able to coordinate the phosphate template. This strategic design allowed the preparation of a hydrolytic imprinted polymer with an impressive pseudo-first-order rate constant 3,200-fold higher than the background reaction and with an imprinting effect of 61.…”

Section: Imprinted Polymers With Metalsmentioning

confidence: 99%

Molecularly imprinted polymers as biomimetic catalysts

Resmini

2012

Anal Bioanal Chem

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The quest for synthetic biomimetic catalysts able to complement the activity of enzymes has attracted substantial research efforts, and the molecular imprinting approach is one of the attractive techniques that are currently being investigated. In the last 3 years, there has been considerable interest in studying in greater detail the parameters that control and influence the catalytic activity of imprinted polymers and applying molecular imprinting to a wider range of polymeric matrices. This article reports on some of the interesting examples available in the literature regarding the use of metal-containing polymers, microgels and nanogels and thermoresponsive polymers.

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Molecularly Imprinted Polymers with Strong Carboxypeptidase A‐Like Activity: Combination of an Amidinium Function with a Zinc‐Ion Binding Site in Transition‐State Imprinted Cavities

Cited by 131 publications

References 27 publications

Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation

Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation

Electrochemical Determination of Tetracycline Using Molecularly Imprinted Polymer Modified Carbon Nanotube‐Gold Nanoparticles Electrode

Molecularly imprinted polymers as biomimetic catalysts

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