2004
DOI: 10.1002/anie.200352770
|View full text |Cite
|
Sign up to set email alerts
|

Molecularly Imprinted Polymers with Strong Carboxypeptidase A‐Like Activity: Combination of an Amidinium Function with a Zinc‐Ion Binding Site in Transition‐State Imprinted Cavities

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
56
0

Year Published

2004
2004
2015
2015

Publication Types

Select...
6
3
1

Relationship

0
10

Authors

Journals

citations
Cited by 131 publications
(56 citation statements)
references
References 27 publications
0
56
0
Order By: Relevance
“…2). Wulff's group [59][60][61] and Resmini's group [62,63] have pioneered in this area. Several polymers mimicking the hydrolytic activity of some enzymes have been synthesized using the TSA approximation, which stabilized the intermediate state and lowered the activation energy.…”
Section: Mip-based Quartz Crystal Microbalance Bioassaysmentioning
confidence: 99%
“…2). Wulff's group [59][60][61] and Resmini's group [62,63] have pioneered in this area. Several polymers mimicking the hydrolytic activity of some enzymes have been synthesized using the TSA approximation, which stabilized the intermediate state and lowered the activation energy.…”
Section: Mip-based Quartz Crystal Microbalance Bioassaysmentioning
confidence: 99%
“…Molecularly imprinted techniques have been shown to be an efficient way of providing functionalized materials and recognizing the specific molecules in a mixture of related compounds [15][16][17]. As reported by Li et al [18], for example, the use of molecularly imprinted polymer (MIP) improved the selectivity of the fluorescent determination of 2,4,6-trinitrotoluene.…”
Section: Introductionmentioning
confidence: 94%
“…The application of metals with the molecular imprinting approach has yet to be fully exploited, especially in the context of developing biomimetic catalysts, although from the examples described later it is clear that there is still a lot of potential. Liu and Wulff [20] reported the synthesis of imprinted polymers mimicking the activity of carboxypeptidase A, by using an amidinium functional monomer and a trialkylamine unit coordinating a Zn(II) atom that was able to coordinate the phosphate template. This strategic design allowed the preparation of a hydrolytic imprinted polymer with an impressive pseudo-first-order rate constant 3,200-fold higher than the background reaction and with an imprinting effect of 61.…”
Section: Imprinted Polymers With Metalsmentioning
confidence: 99%