Molecularly-imprinted polymers for the separation and detection of curcumin

Ranjbari, Sara; Mohammadinejad, Arash; Johnston, Thomas P.; Kesharwani, Prashant; Oskuee, Reza Kazemi; Rezayi, Majid; Sahebkar, Amirhossein

doi:10.1016/j.eurpolymj.2023.111916

Cited by 16 publications

(3 citation statements)

References 89 publications

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“…This technique creates molecular cavities in the polymeric matrix, which are produced in the presence of template molecules, forming artificial binding sites, which leads to an enhancement in the selectivity of the sensor. 65,66 Alternatively, the surface of electrodes can be modified using metal-polymer NCs via different pathways such as polymerization with subsequent metal ion reduction, metal ion reduction with subsequent polymerization, and direct adsorption (Fig. 3).…”

Section: Metal-synthetic Polymer Ncs As Electrode Modifiers For Sensi...mentioning

confidence: 99%

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Zahran

2024

Mater. Adv.

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Section: Metal-synthetic Polymer Ncs As Electrode Modifiers For Sensi...mentioning

confidence: 99%

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Zahran

2024

Mater. Adv.

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“…MIPs have the ability to specifically recognize template molecules, being considered excellent recognition elements for the construction of electrochemical sensors for curcumin [74]. Generally, they are produced by polymerization in the presence of the target (template) with functional and crosslinking monomers.…”

Section: Molecular-imprinting-polymer-modified Electrodesmentioning

confidence: 99%

Electrochemical Sensing of Curcumin: A Review

Chiorcea-Paquim

2023

Antioxidants

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Curcumin is a natural polyphenol derived from turmeric (Curcuma longa) root that has been used for centuries as a spice, coloring agent, and medicine. Curcumin presents anti-inflammatory, antioxidant, anticarcinogenic, antimicrobial, antiviral, antimalarial, hepatoprotective, thrombosuppressive, cardiovascular, hypoglycemic, antiarthritic, and anti-neurodegenerative properties. It scavenges different forms of free radicals and acts on transcription factors, growth factors and their receptors, cytokines, enzymes, and genes, regulating cell proliferation and apoptosis. Curcumin is electroactive, and a relationship between its electron transfer properties and radical-scavenging activity has been highlighted. The objective of this review is to provide a comprehensive overview of the curcumin electron transfer reactions, with emphasis on the controversial aspects related to its oxidation mechanism. The final sections will focus on the electroanalysis of curcumin in natural products, highlighting the most important sensing strategies, based on functional electrodes and nanostructured materials, essential for the development of more efficient in vitro methods of detection and quantification of curcumin in food samples, supplements, and nutripharmaceuticals.

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“…Furthermore, a recent review article discusses the utilization of various functional monomers in preparing imprinted polymers for curcumin. These monomers include 4-pentenoyl-alanyl-chitosan oligosaccharide, N -isopropylacrylamide, acrylamide, methacrylamide, and 4-vinylpyridine …”

Section: Introductionmentioning

confidence: 99%

Rational Design of Molecularly Imprinted Polymers for Curcuminoids Binding: Computational and Experimental Approaches for the Selection of Functional Monomers

Muñoz,

Orozco,

Hoyos

et al. 2024

J. Chem. Inf. Model.

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Molecularly imprinted polymers (MIPs) have emerged as bespoke materials with versatile molecular applications. In this study, we propose a proof of concept for a methodology employing molecular dynamics (MD) simulations to guide the selection of functional monomers for curcuminoid binding in MIPs. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin are phenolic compounds widely employed as spices, pigments, additives, and therapeutic agents, representing the three main curcuminoids of interest. Through MD simulations, we investigated prepolymerization mixtures composed of various functional monomers, including acrylamide (ACA), acrylic acid (AA), methacrylic acid (MAA), and N-vinylpyrrolidone (NVP), with ethylene glycol dimethacrylate (EGDMA) as the cross-linker and acetonitrile as the solvent. Curcumin was selected as the template molecule due to its structural similarity to the other curcuminoids. Notably, the prepolymerization mixture containing NVP as the functional monomer demonstrated superior molecular recognition capabilities toward curcumin. This observation was supported by higher functional monomer molecules surrounding the template, a lower total nonbonded energy between the template and monomer, and a greater number of hydrogen bonds in the aggregate. These findings suggest a stronger affinity between the functional monomer NVP and the template. We synthesized, characterized, and conducted binding tests on the MIPs to validate the MD simulation results. The experimental binding tests confirmed that the MIP-NVP exhibited higher binding capacity. Consequently, based on MD simulations, our computational methodology effectively guided the selection of the functional monomer, leading to MIPs with binding capacity for curcuminoids. The outcomes of this study provide a valuable reference for the rational design of MIPs through MD simulations, facilitating the selection of components for MIPs. This computational approach holds the potential for extension to other templates, establishing a robust methodology for the rational design of MIPs.

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Molecularly-imprinted polymers for the separation and detection of curcumin

Cited by 16 publications

References 89 publications

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Electrochemical Sensing of Curcumin: A Review

Rational Design of Molecularly Imprinted Polymers for Curcuminoids Binding: Computational and Experimental Approaches for the Selection of Functional Monomers

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