Molecularly imprinted polymers-based DNA biosensors

Nawaz, Noman; Bakar, Nor Kartini Abu; Mahmud, Habibun Nabi Muhammad Ekramul; Jamaludin, Nazzatush Shimar

doi:10.1016/j.ab.2021.114328

Cited by 53 publications

(32 citation statements)

References 81 publications

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“…Nevertheless, the synthesis of molecularly imprinted polymers (MIPs) was boosted by Wulff and Mosbach later in the 1970s [ 22 , 23 ]. Since then, a broad spectrum of analytes including low-molecular-weight molecules, such as pharmaceuticals, sugars, toxins, narcotic drugs, pesticides, and biomacromolecules such as proteins, nucleic acids, bacteria, and viruses have been described [ 20 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

Yarman

Kurbanoğlu

2022

Biomimetics

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Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has played a major role worldwide. For this reason, various methods have been developed, comprising reverse transcriptase-polymerase chain reaction (RT-PCR), immunoassays, clustered regularly interspaced short palindromic repeats (CRISPR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and bio(mimetic)sensors. Among the developed methods, RT-PCR is so far the gold standard. Herein, we give an overview of the MIP-based sensors utilized since the beginning of the pandemic.

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Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

Yarman

Kurbanoğlu

2022

Biomimetics

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“…Among a plethora of polymer-based matrices for biosensing applications, MIPs are commonly used as artificial recognition moieties, particularly as “synthetic antibodies” referred to as “plastobodies”, to emphasize the analogy to specific binding by antibodies [ 2 , 8 , 9 , 15 ]. Molecular imprinting technology has been adopted for the electroanalytical determination of various antibiotics [ 18 , 19 , 20 , 21 ], herbicides [ 22 , 23 ], pesticides [ 24 ], drugs [ 25 ], and macromolecular compounds, from oligonucleotides [ 26 , 27 ] to carbohydrates [ 28 , 29 , 30 ], and proteins [ 4 , 15 , 17 , 31 ]. Unlike small molecular targets, proteins show “special” properties, such as their size, irreversible conformational changes, and secondary and tertiary structure.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, a wealth of different synthetic strategies were presented to facilitate the design of efficient, imprinted materials for the application of interest. More detailed explanations of the synthesis, application, and limitations of MIPs can be found recent reviews [ 2 , 12 , 14 , 17 , 24 , 27 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial Biomimetic Electrochemical Assemblies

et al. 2022

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Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining popularity due to their ability to design sensor platforms that are selective to determine target analytes. Naturally generated receptor units have a high affinity for their targets, which provides the selectivity of a device. However, such receptors are subject to instability under harsh environmental conditions and have consequently low durability. By applying principles of supramolecular chemistry, molecularly imprinted polymers (MIPs) can successfully replace natural receptors to circumvent these shortcomings. This review summarizes the recent achievements and analytical applications of electrosynthesized MIPs, in particular, for the detection of protein-based biomarkers. The scope of this review also includes the background behind electrochemical readouts and the origin of the gate effect in MIP-based biosensors.

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“… 20 , 21 Molecular imprinting has been investigated for a wide range of applications, including chromatography, 22 drug delivery, 23 and biosensing. 24 It is expected that nanofibrous adsorbent materials could be fabricated with molecular recognition sites on the surface by applying molecular imprinting technology. 25 , 26 …”

Section: Introductionmentioning

confidence: 99%

Electrospun Porous Nanofibers with Imprinted Patterns Induced by Phase Separation of Immiscible Polymer Blends

et al. 2022

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Nanofibrous nonwoven fabrics have attracted attention as porous adsorbents with high specific surface areas for the safe and efficient treatment of spilled organic dyes and petroleum. For this purpose, a method of fabricating porous nanofibers with high specific surface areas would be highly beneficial. In this study, the phase separation in nanofibers electrospun from blended solutions of immiscible polymers [poly(styrene) (PS) and poly(vinylpyrrolidone) (PVP)] was investigated. The removal of PVP as a sacrificial polymer afforded the imprinting of mesopores (40–70 nm) in the PS nanofibers. The effects of solution composition (PS/PVP in N , N -dimethylformamide) on the structure formation in the fibers were investigated. The nanofibers thus obtained could selectively adsorb low-molecular-weight hydrophobic dyes, such as Nile Red and Oil Red O. Thus, it is expected that the combined approach of electrospinning of immiscible polymer blends and phase separation-induced patterning can be applied to the fabrication of functional nanofibers for diverse applications.

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Molecularly imprinted polymers-based DNA biosensors

Cited by 53 publications

References 81 publications

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

Artificial Biomimetic Electrochemical Assemblies

Electrospun Porous Nanofibers with Imprinted Patterns Induced by Phase Separation of Immiscible Polymer Blends

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