Molecularly imprinted polymers as receptor mimics for selective cell recognition

Abstract

Molecularly imprinted polymers (MIPs) have now earned the reputation as "artificial receptors" or "plastic antibodies". As the mimics of natural receptors, MIPs are reminiscent of some basic functions of natural receptors in living systems, e.g., the ability to interact with or recognize cells. The latest decade has witnessed a great advance in MIPs from simple molecular extraction to efficient cell recognition, implying that MIP-based synthetic receptors are approaching to be perfectly functioning replicates of their natural counterparts. With the most emerging development in molecular imprinting, MIP-mediated cell recognition has now shown great promise in cell biology research, theranostics and regenerative medicine. This tutorial review provides a panoramic view of current MIPs for both microorganism and mammalian cell recognition. The most representative developments of MIP-mediated cell recognition, from initial imprinting strategies to eventual bio-related applications, are highlighted.

Electrochemical biosensors for pathogen detection

“…Given traditional biorecognition elements used in biosensing exhibit stability concerns, such as antibodies or aptamers, as discussed in Sections 2.2.1-2.2.4, there have been efforts to create engineered molecular biorecognition elements, such as scFvs. In contrast, materials-based biorecognition elements exploit the principle of target-specific morphology for selective capture (Pan et al 2018;Zhou et al 2019). The most common approach in materials-based biorecognition is based on cell-and molecularly-imprinted polymers (CIPs and MIPs, respectively) (Gui et al 2018).…”

“…The most common approach in materials-based biorecognition is based on cell-and molecularly-imprinted polymers (CIPs and MIPs, respectively) (Gui et al 2018). CIPs and MIPs have been created using various processes, including bacteria-mediated lithography, micro-contact stamping, and colloid imprints (Chen et al 2016a;Pan et al 2018).…”

Molecularly Imprinted Materials for Selective Biological Recognition

“…There is no doubt that imprinting encountered considerable obstacles. In the future, the recognition of cell membrane by CIPs still depends on the development of cell biology, targeted molecular imprinting, and the reduction of non‐specific adsorption…”

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

“…Owing to the specific molecular recognition capability, molecularly imprinted polymers (MIPs) have attracted enormous interest in applied science and technology areas. Molecular imprinting has been widely used to prepare robust polymer materials with predefined molecular selectivity for applications such as affinity‐based separations, solid phase extraction in analytical sample preparation, controlled delivery of therapeutic drugs, and chemical sensors . Molecular imprinting technique involves the preparation of a synthetic polymer through the cross‐linking of functional monomers in the presence of a molecular template.…”

“…Molecular imprinting has been widely used to prepare robust polymer materials with predefined molecular selectivity for applications such as affinity-based separations, solid phase extraction in analytical sample preparation, controlled delivery of therapeutic drugs, and chemical sensors. [1][2][3][4] Molecular imprinting technique involves the preparation of a synthetic polymer through the cross-linking of functional monomers in the presence of a molecular template. In the first step, a templatefunctional monomer complex is formed through covalent or non-covalent interactions.…”