Molecularly Imprinted Polymers

Sellergren, Börje; Hall, Andrew J.

doi:10.1002/9780470661345.smc137

Cited by 55 publications

(63 citation statements)

References 105 publications

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“…The design of highly specific imprinted must be made avoiding the covalent binding of the template molecules to the tailored-cavities, since it would compromise the fast equilibrium and reversible binding by reusable potentiometric sensing devices (Sellergren, 2001). Non-covalent binding leads to sites that are less oriented than those in covalent imprinting but a careful design must lead to similar selectivity and sensitivity.…”

Section: Resultsmentioning

confidence: 99%

Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline

Moreira

Kamel

Guerreiro

et al. 2010

Biosensors and Bioelectronics

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Section: Resultsmentioning

confidence: 99%

Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline

Moreira

Kamel

Guerreiro

et al. 2010

Biosensors and Bioelectronics

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“…4), inferring the existence of high and low affinity populations of binding sites (Sellergren, 2001). K d1 and Qmax were, respectively, 0.21 µmol/L and 49 µmol/g for the high affinity binding sites, and 12 µmol/L and 163 µmol/g for the low affinity binding sites.…”

Section: Rebinding Properties Of the Imprinted Materialsmentioning

confidence: 96%

“…The resulting binding capacity was calculated by Eq. (1): ysis, providing important information on binding properties of the imprinted particles (Sellergren, 2001). The Scatchard equation, was applied for this purpose, where Q is the binding capacity; C free the free analytical concentration at equilibrium (µmol/L); Qmax is the maximum apparent binding capacity; and K d is the dissociation constant at binding site.…”

Section: Rebinding Properties Of the Imprinted Materialsmentioning

confidence: 99%

Myoglobin-biomimetic electroactive materials made by surface molecular imprinting on silica beads and their use as ionophores in polymeric membranes for potentiometric transduction

Moreira

Dutra

Noronha

et al. 2011

Biosensors and Bioelectronics

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Myoglobin (Mb) is among the cardiac biomarkers playing a major role in urgent diagnosis of cardio-vascular diseases. Its monitoring in point-ofcare is therefore fundamental. Pursuing this goal, a novel biomimetic ionophore for the potentiometric transduction of Mb is presented. It was synthesized by surface molecular imprinting (SMI) with the purpose of developing highly efficient sensor layers for near-stereochemical recognition of Mb. The template (Mb) was imprinted on a silane surface that was covalently attached to silica beads by means of self-assembled monolayers. First the silica was modified with an external layer of aldehyde groups. Then, Mb was attached by reaction with its amine groups (on the external surface) and subsequent formation of imine bonds. The vacant places surrounding Mb were filled by polymerization of the silane monomers 3-aminopropyltrimethoxysilane (APTMS) and propy-ltrimethoxysilane (PTMS). Finally, the template was removed by imine cleavage after treatment with oxalic acid. The results materials were finely dispersed in plasticized PVC selective membranes and used as ionophores in potentiometric transduction. The best analytical features were found in HEPES buffer of pH 4. Under this condition, the limits of detection were of 1.3 × 10 −6 mol/L for a linear response after 8.0 × 10 −7 mol/L with an anionic slope of −65.9 mV/decade. The imprinting effect was tested by prepar-ing non-imprinted (NI) particles and employing these materials as ionophores. The resulting membranes showed no ability to detect Mb. Good selectivity was observed towards creatinine, sacarose, fructose, galactose, sodium glutamate, and alanine. The analytical application was conducted successfully and showed accurate and precise results.

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“…EGDMA is the most commonly used cross-linker for the methacrylate-based system, primarily because it provides materials with mechanical and thermal stability, good wettability in most rebinding media, and rapid mass transfer with good recognition properties [22]. Except for trimethacrylate monomers, such as TRIM can provide similar recognition properties for such a large variety of templates [23]. RIM was used to prepare a molecularly imprinted solid-T phase extraction (MISPE) sorbent possessing the highest binding selectivity and binding capability for the template tebuconazole [24].…”

Section: Selection Of Cross-linkermentioning

confidence: 99%

Molecularly Imprinted Micro-Solid-Phase Extraction for the Selective Determination of Phenolic Compounds in Environmental Water Samples with High Performance Liquid Chromatraphy

Feng¹,

Chen²,

Xu³

et al. 2013

OJPChem

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ABSTRACT2,4,6-trichlorophenol molecularly imprinted suspension polymer has been prepared and applied to the molecularly imprinted micro-solid-phase extraction procedure for selective preconcentration of phenolic compounds from environmental water samples. The influence of functional monomer, cross-linker, polymerization condition, porogen, and the ratio of template molecule and functional monomer to cross-linker on the size of the obtained particles were investigated. It was found that methyacrylic acid as functional monomer, divinylbenzene as cross-linker, the molar ratio of template molecule and functional monomer to cross-linker was 1:4:20, the amount of AIBN was 100 mg, ultraviolet radiation at 365 nm were the optimal conditions, and at these conditions, the polymers had the best adsorption efficiency and had the monodispersity of 2 -3 μm microsphere particles. The characteristics of the MIMSPE method were valid by high performance liquid chromatography. This MIMSPE-HPLC method has been successfully applied to the direct preconcentration and determination of phenolic compounds (phenol, 4-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol) in environmental water samples.

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Molecularly Imprinted Polymers

Abstract: The version in the Kent Academic Repository may differ from the final published version. Users are advised to check http://kar.kent.ac.uk for the status of the paper. Users should always cite the published version of record.

Cited by 55 publications

References 105 publications

Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline

Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline

Myoglobin-biomimetic electroactive materials made by surface molecular imprinting on silica beads and their use as ionophores in polymeric membranes for potentiometric transduction

Molecularly Imprinted Micro-Solid-Phase Extraction for the Selective Determination of Phenolic Compounds in Environmental Water Samples with High Performance Liquid Chromatraphy

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