Molecularly imprinted polymer with salicylaldehyde-Cu(OAc)2 as template

Abstract

In the report molecularly imprinted polymer (MIP) with salicylaldehyde-Cu(OAc)(2) as the template was synthesized and characterized by SEM, porosity and elemental analysis. Copper acetate was introduced since salicylaldehyde alone cannot display imprinting effect for its intramolecular hydrogen bond. The strong coordination interaction between salicylaldehyde and copper acetate made the complex have high retention on the HPLC column based on the SAD-Cu(OAc)(2) imprinted polymer. Several structural analogues such as salicylaldoxime, sulfosalicylic acid, p-hydroxybenzaldehyde and their complexes with copper acetate were chosen to study the selectivity of the MIPs. The influence of acetic acid and H(2)O in methanol mobile phase was studied. The experimental results showed that small amount of either acetic acid or H(2)O in mobile phase would weaken the interaction between the complex and the polymer, therefore, the retention of the complex was lowered to a large extent, but that of salicylaldehyde remained almost unchanged. The polymer imprinted with the complex showed high selectivity to both the acetate and copper (II). In addition, the MIP showed an enhanced selectivity to its template compared with the polymer prepared without copper acetate.

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

“…The demonstration of template (or template analog)‐selective recognition by an MIP remains a cornerstone in the development of all new MIP systems. Various strategies have been employed to characterize ligand‐polymer binding events,…”

Receptor‐attached amphiphilic terpolymer for selective drug recognition in aqueous solutions

“…The area of polymer therapeutics, in particular, has evolved to include polymer-drug and polymer-protein conjugates, molecularly imprinted polymers (Yang and Li, 2005;Huiqi et al, 2006;Ye and Mosbach, 2008;Meng et al, 2009), and polymeric micelles containing covalently bound drugs (Kolhe et al, 2004;Patri et al, 2005;Khandare and Minko, 2006;Vicent and Duncan, 2006;Boyer et al, 2007;Fox et al, 2009;Krakoviˇcová et al, 2009;Prabaharan et al, 2009). The hydrophilic corona of the micelle renders the polymer water-soluble and its hydrophobic core provides a suitable environment that can physically entrap drugs and facilitate their transport to the targeted site at concentrations independent of the drug's intrinsic water solubility (Velluto et al, 2008).…”

MMTCA Recognition by Molecular Imprinting in Interpenetrating Polymer Network Hydrogels Based on Poly(acrylic acid) and Poly(vinyl alcohol)

“…Molecular imprinting is an emerging technology, which allows the synthesis of materials containing highly specific receptor sites with an affinity for target compounds. The molecular imprinting technique involves forming a pre‐polymerization complex between the imprinted molecule and the functional monomer with specific chemical structure designed to interact with the imprinted molecule either by covalent1, 2 or non‐covalent3, 4 interactions or by metal ion coordination 5–7. These complexes are fixed by polymerization with a certain degree of crosslinking.…”