Molecularly imprinted polymer SPE sensor for analysis of CA-125 on serum

Rebelo, Tânia S.C.R.; Costa, Renata; Brandão, Ana T. S. C.; Silva, A. Fernando; Sales, M. Goreti F.; Pereira, Carlos M.

doi:10.1016/j.aca.2019.07.050

Cited by 74 publications

(33 citation statements)

References 52 publications

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“…Subsequently, pyrrole was polymerised into a thin film and the template was finally removed by incubating the electrode in a sodium dodecyl sulfate solution. The sensor was capable of detecting over a wider concentration range with the electrochemical investigation strategy (0.01-500 U mL −1 ) in comparison to the SPR strategy (0.1-300 U mL −1 ) [67]. Nevertheless, the linear response range was far broader than the similarly developed surface plasmon resonance imaging immunosensor reported by Szymańska's group, which was only 2.2-150 U mL −1 of CA-125 [68].…”

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 82%

“…Furthermore, the sensor showed a performance similar to enzyme-linked immunosorbent assay (ELISA) in serum [66]. Rebelo et al developed a MIP-based sensor capable of detecting carbohydrate antigen 125 (CA-125), a biomarker for several types of cancer, via optical (SPR) as well as electrochemical (square wave voltammetry) techniques [67]. The imprinting process involved SAM formation of cysteamine on a screen-printed gold electrode that encouraged CA-125 adsorption.…”

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

“…Nevertheless, the linear response range was far broader than the similarly developed surface plasmon resonance imaging immunosensor reported by Szymańska's group, which was only 2.2-150 U mL −1 of CA-125 [68]. Although the MNP-based SPR sensor reported by Pal et al provided a multiplex-based assay for the detection of CA-125 as well as other ovarian cancer biomarkers (β2-microglobulin and Apo-lipoprotein A1), the calibration curves revealed an even narrower linear response range for CA-125 (5.0-40.0 U mL −1 ) [69] than the former two studies [67,68]. Thus, a comparison between the three studies established the superiority of molecular imprinting over antibody-based receptors.…”

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

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Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 82%

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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“…Similarly, tryptophan has been measured in human serum with MIPs composited with carbon nanotubes (106). Lastly, cancer detection has been evaluated through a comparison of MIPbased optical and ECM biosensors (107). More examples are contained throughout this review.…”

Section: Biosensor Applicationsmentioning

confidence: 99%

“…A valuable report was published recently in which the authors disclose the comparison of an ECM biosensor with an optical biosensor, namely SPR, both of which were functionalized with MIPs (107). The fabrication of the sensors followed similar designs.…”

Section: Optical Transductionmentioning

confidence: 99%

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

Denmark

Mohapatra

2020

The EuroBiotech Journal

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Significant healthcare disparities resulting from personal wealth, circumstances of birth, education level, and more are internationally prevalent. As such, advances in biomedical science overwhelmingly benefit a minority of the global population. Point-of-Care Testing (POCT) can contribute to societal equilibrium by making medical diagnostics affordable, convenient, and fast. Unfortunately, conventional POCT appears stagnant in terms of achieving significant advances. This is attributed to the high cost and instability associated with conventional biorecognition: primarily antibodies, but nucleic acids, cells, enzymes, and aptamers have also been used. Instead, state-of-the-art biosensor researchers are increasingly leveraging molecularly imprinted polymers (MIPs) for their high selectivity, excellent stability, and amenability to a variety of physical and chemical manipulations. Besides the elimination of conventional bioreceptors, the incorporation of nanomaterials has further improved the sensitivity of biosensors. Herein, modern nanobiosensors employing MIPs for selectivity and nanomaterials for improved transduction are systematically reviewed. First, a brief synopsis of fabrication and wide-spread challenges with selectivity demonstration are presented. Afterward, the discussion turns to an analysis of relevant case studies published in the last five years. The analysis is given through two lenses: MIP-based biosensors employing specific nanomaterials and those adopting particular transduction strategies. Finally, conclusions are presented along with a look to the future through recommendations for advancing the field. It is hoped that this work will accelerate successful efforts in the field, orient new researchers, and contribute to equitable health care for all.

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Surface Plasmon Resonance Sensors Based on Molecularly Imprinted Polymers

Esen

Piletsky

2021

Plasmonic Sensors and Their Applications

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Molecularly imprinted polymer SPE sensor for analysis of CA-125 on serum

Cited by 74 publications

References 52 publications

Recent Progress in Optical Sensors for Biomedical Diagnostics

Recent Progress in Optical Sensors for Biomedical Diagnostics

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

Surface Plasmon Resonance Sensors Based on Molecularly Imprinted Polymers

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