Molecularly imprinted polymer nanomaterials and nanocomposites by controlled/living radical polymerization

Beyazıt, Selim; Bui, Bernadette Tse Sum; Haupt, Karsten; Gonzato, Carlo

doi:10.1016/j.progpolymsci.2016.04.001

Cited by 151 publications

(108 citation statements)

References 142 publications

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“…These unstable initiators make the process very unpredictable and uncontrollable . Hence, living radical polymerization (LRP) was adopted in a bid to circumvent the existing limitations . The usage of LRP is of great convenience as it reduces the need for strict purification of the reactants and allows the utilization and presence of different functional groups during and after the polymerization process .…”

Section: Polymerization Techniquesmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

121

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With the advancement of polymer engineering, complex star-shaped polymer architectures can be synthesized with ease, bringing about a host of unique properties and applications. The polymer arms can be functionalized with different chemical groups to fine-tune the response behavior or be endowed with targeting ligands or stimuli responsive moieties to control its physicochemical behavior and self-organization in solution. Rheological properties of these solutions can be modulated, which also facilitates the control of the diffusion of the drug from these star-based nanocarriers. However, these star-shaped polymers designed for drug delivery are still in a very early stage of development. Due to the sheer diversity of macromolecules that can take on the star architectures and the various combinations of functional groups that can be cross-linked together, there remain many structure-property relationships which have yet to be fully established. This review aims to provide an introductory perspective on the basic synthetic methods of star-shaped polymers, the properties which can be controlled by the unique architecture, and also recent advances in drug delivery applications related to these star candidates.

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Section: Polymerization Techniquesmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

121

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“…Molecular imprinting technique allows the creation of polymeric networks bearing specific binding sites for a predetermined molecule (drug template) via polymerization [27][28][29][30][31]. MIP synthesis is a relatively straightforward and inexpensive procedure, based on mixing the template molecules with a proper functional monomer, in the presence of a crosslinking agent and an initiator in a porogenic solvent.…”

Section: Molecular Imprintingmentioning

confidence: 99%

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.Polymers 2019, 11, 2085 2 of 33 normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.Polymers 2019, 11, x FOR PEER REVIEW 2 of 34 of both normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.

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“…As well known, structure determines nature of substances. Considering diverse applications of imprinted materials in different fields, more emphasis and design should be put on the size, morphology and properties of imprinted materials themselves. For example, in the field of electrochemical sensing, facile to be polymerized on electrodes, high specific surface area, and superior mechanical strength are characteristics required of imprinted materials .…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Materials for Selective Biological Recognition

Zhang

et al. 2019

Macromol. Rapid Commun.

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Molecular imprinting is an approach of generating imprinting cavities in polymer structures that are compatible with the target molecules. The cavities have memory for shape and chemical recognition, similar to the recognition mechanism of antigen–antibody in organisms. Their structures are also called biomimetic receptors or synthetic receptors. Owing to the excellent selectivity and unique structural predictability of molecularly imprinted materials (MIMs), practical MIMs have become a rapidly evolving research area providing key factors for understanding separation, recognition, and regenerative properties toward biological small molecules to biomacromolecules, even cell and microorganism. In this review, the characteristics, morphologies, and applicability of currently popular carrier materials for molecular imprinting, especially the fundamental role of hydrogels, porous materials, hierarchical nanoparticles, and 2D materials in the separation and recognition of biological templates are discussed. Moreover, through a series of case studies, emphasis is given on introducing imprinting strategies for biological templates with different molecular scales. In particular, the differences and connections between small molecular imprinting (bulk imprinting, “dummy” template imprinting, etc.), large molecular imprinting (surface imprinting, interfacial imprinting, etc.), and cell imprinting strategies are demonstrated in detail. Finally, future research directions are provided.

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Molecularly imprinted polymer nanomaterials and nanocomposites by controlled/living radical polymerization

Cited by 151 publications

References 142 publications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Molecularly Imprinted Materials for Selective Biological Recognition

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