Molecularly imprinted polymer microspheres prepared via the two‐step swelling polymerization for the separation of lincomycin

Abstract

A molecularly imprinted polymer (MIP) was synthesized via a two-step swelling polymerization method for the purification of lincomycin. Polystyrene microspheres were prepared by the dispersion-polymerization process and used as the substrate. Methacrylic acid was used as the functional monomer, whereas ethylene glycol dimethacrylate was the cross-linker. The MIP was structurally characterized and examined for its separation performance at different conditions (temperature, solvents, etc.). It was found that the MIP possesses the good sphericity, porosity, monodispersity, and a high adsorption capacity of (180 μmol/g) in chloroform solution. Comparison studies showed that the MIP presents a higher capacity than the NIP (non-imprinted polymer) in chloroform solution and a much higher capacity in the practical lincomycin fermentation solution extracts, confirming the underlining mechanisms of the MIP. Scatchard plot revealed two adsorption mechanisms on the MIP, whereas the isotherm is better described by Freundlich equation. The adsorption/elution kinetics demonstrated that the MIP possesses good elution/regeneration capabilities with the elution ratio > 93%.

A molecularly imprinted polymer for the efficient adsorption of morphine

“…The MIP is a 3D crosslinked polymeric adsorbent with specific binding sites generated by the molecular‐imprinting process 12 . These sites (or cavities) are complementary to the geometry and surface chemistry of the template molecule so that they present good adsorption selectivity and capability in a complex solution of mixtures 12–14 . This technology has been quickly developed and widely used in sensing technologies 15,16 and separation applications of metal ions, 13 vitamins, 17 antibiotics, 14 proteins, 18,19 and chiral molecules, 20 etc.…”

Chemical Imaging of Single Anisotropic Polystyrene/Poly (Methacrylate) Microspheres with Complex Hierarchical Architecture

“…The availability of synthetic procedures leading to polystyrene spheres with narrow size distributions and their ability to swell in different media make them ideal templates for the generation of more complex isotropic and anisotropic materials [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. For this purpose, it is important to control specific particle properties, such as size and size distribution, shape, surface porosity, and chemical composition during synthesis [ 11 ].…”

Self-Driven BSA Surface Imprinted Magnetic Tubular Carbon Nanofibers: Fabrication and Adsorption Performance

“…2−4 MIPs have advantages of good chemical and mechanical stability, selectivity, reusability, and ease of preparation. They are widely used in purification and separation, 5 solid-phase extraction, 6−8 simulated enzyme catalysis, 9 chemical sensors, 10−12 etc. Along with the wide development of MIT to this day, the research on small molecule imprinting has been flourishing.…”

“…Thus, MIPs can specifically recognize the template molecules from certain environments. − MIPs have advantages of good chemical and mechanical stability, selectivity, reusability, and ease of preparation. They are widely used in purification and separation, solid-phase extraction, − simulated enzyme catalysis, chemical sensors, − etc. Along with the wide development of MIT to this day, the research on small molecule imprinting has been flourishing. , However, the imprinting of biomacromolecules such as peptides and proteins still faces great challenges.…”