Molecularly imprinted polymer for solid‐phase extraction of ephedrine and analogs from human plasma

Abstract

A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ephedrine from human plasma. The MIP synthesis was performed in chloroform with methacrylic acid as a functional monomer and the target alkaloid as a template molecule. The resulting MIP was applied to the selective extraction of ephedrine from a pure aqueous medium. A recovery about 74% was obtained using the MIP with only 7% on the nonimprinted polymer (NIP). A very straightforward selective SPE procedure was then successfully applied to the direct extraction of ephedrine from spiked human plasma with a high extraction recovery (68%) on the MIP with no recovery on the NIP. Moreover, the MIP was used for the selective extraction of catecholamine neurotransmitters, i.e. adrenaline and noradrenaline.

On‐line solid‐phase extraction for liquid chromatography–mass spectrometry analysis of pesticides

“…In the last few years, other novel material technology, such as monoliths [45], MIP [45,46], immunoaffinity columns, and hydrophilic polymeric sorbents have also been introduced as SPE sorbents. For instance, MIPs are synthetic and intelligent materials with an artificially generated three-dimensional network that is able to specifically rebind a target molecule [45][46][47][48][49]. MIP has the advantages to be cost-effective, and chemically and thermally stable without storage limitations and stability problems regarding organic solvents [50,51].…”

Determination of urinary 8‐hydroxy‐2′‐deoxyguanosine by a combination of on‐line molecularly imprinted monolithic solid phase microextraction with high performance liquid chromatography–ultraviolet detection

“…But with the extending length, the flow resistance increased and higher pressure needed for extraction operation. On account of duration of monolithic column and extraction efficiency as well as sustainability of the column, different length of MIP monolith (8,10,12,15,18, and 20 cm) were synthesized and their extraction performances were investigated in the study. Among them, 15 cm long monolithic column was the optimal one for SPME operation.…”

“…Molecularly imprinted polymers (MIPs) have attracted wide attention because they show promise as selective medium of separation. The application of MIPs as sorbent of sample treatment allows selective extraction of target analyte from complex matrix, which is significant to trace analyte determination in biological or environmental sample [15].…”

Development of molecularly imprinted microspheres for the fast uptake of 4-cumylphenol from water and soil samples

“…SPE is the most common sample preparation technique used for the analysis of various environmental toxins [19][20][21]. The potential of SPE has also been explored to make it specific and selective by its combination with molecularly imprinted sorbents [22][23][24]. Molecularly imprinted sorbents, materials containing specific pockets for the recognition of a particular target, can be synthesized by bulk polymerization [25], suspension polymerization [26], emulsion polymerization [27] two-step polymerization [28], and precipitation polymerization [29].…”