Molecularly imprinted polymer for caffeic acid by precipitation polymerization and its application to extraction of caffeic acid and chlorogenic acid from Eucommia ulmodies leaves

Miura, Chitose; Matsunaga, Hisami; Haginaka, Jun

doi:10.1016/j.jpba.2015.12.052

Cited by 31 publications

(7 citation statements)

References 27 publications

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“…The ratio of the template to functional monomer and cross-linker used was 1:4:20 based on previous MIP synthesis performed by our group [ 33 ]. For the solvent choice, several studies used a mixture of acetonitrile and toluene [ 34 ] for the synthesis of MIP specific to CA. Toluene allows the solubilization of caffeic acid, but given its high toxicity, it was replaced by methanol in this study.…”

Section: Resultsmentioning

confidence: 99%

Combination of Screen-Printed Carbon Electrode and Molecularly Imprinted Polymers for the Selective Determination of Phenolic Compounds in Wine

et al. 2022

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Caffeic acid (CA) is an efficient antioxidant found in wine and in plants and can be extracted from the by-products of the food industry. A molecularly imprinted polymer specific to caffeic acid (CA-MIP) was prepared by radical polymerization using N-phenylacrylamide as the functional monomer, ethylene glycol dimethacrylate as the cross-linker, and azobisisobutyronitrile as the initiator, in the presence of CA as the template molecule. The rebinding activities between the polymers and CA were promoted by an indirect method and characterized by cyclic voltammetry (CV) using a screen-printed carbon electrode (SPCE). It is a fast method, which only requires simple and portable instrumentation. The polymer showed a high selectivity toward CA and a good repeatability. CA-MIP was then applied in wine samples spiked with CA, and the results were compared to those obtained by a chromatographic method. With a limit of detection of 0.06 mM in wine, the recovery values confirmed that the method is suitable for further applications.

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Section: Resultsmentioning

confidence: 99%

Combination of Screen-Printed Carbon Electrode and Molecularly Imprinted Polymers for the Selective Determination of Phenolic Compounds in Wine

et al. 2022

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“…Iridoid glycosides, spiramycin, 2,4-dichlorophenoxyacetic acid, diclofenac, alfatoxins [17][18][19][20][21] Suspension polymerization Malachite green, p-hydroxybenzoic acid, timolol, alfatoxins B1, Pb 2+ [22][23][24][25][26] Emulsion polymerization Quercetin, malachite green, Listeria monocytogenes, triazines, Cd 2+ [27][28][29][30][31] Seed polymerization Nicotinamide, bisphenol A, promazine derivates [32][33][34] Precipitation polymerization Triclosan and triclocarban, strychnine, caffeic acid, vitamin E, prednisolone [35][36][37][38][39] RAFT polymerization Benzimidazole, propranolol, polycyclic aromatic hydrocarbons [40][41][42] Atom transfer radical polymerization Ofloxacin, ␤2-agonists [43,44] Sol-gel Iprodione, methylxanthines [45,46] RAFT: Reversible addition fragmentation chain transfer.…”

Section: Bulk Polymerizationmentioning

confidence: 99%

Molecularly Imprinted Polymers in Biological Applications

et al. 2020

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Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

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“…It can be also found in vegetables, beverages, olive oil, and many medicinal plants [ 7 , 92 , 93 ]. Although it is believed that coffee is a major source of CA human intake, the novel approaches for its extraction consider herbs/plants and the use of methods assisted by ultrasonic, supercritical fluids, and molecularly imprinted polymers [ 94 , 95 , 96 , 97 ].…”

Section: Hydroxycinnamic Acidsmentioning

confidence: 99%

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

Ojeda-Hernández

Canales-Aguirre²,

Matías‐Guiu

et al. 2022

IJMS

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Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.

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Molecularly imprinted polymer for caffeic acid by precipitation polymerization and its application to extraction of caffeic acid and chlorogenic acid from Eucommia ulmodies leaves

Cited by 31 publications

References 27 publications

Combination of Screen-Printed Carbon Electrode and Molecularly Imprinted Polymers for the Selective Determination of Phenolic Compounds in Wine

Combination of Screen-Printed Carbon Electrode and Molecularly Imprinted Polymers for the Selective Determination of Phenolic Compounds in Wine

Molecularly Imprinted Polymers in Biological Applications

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

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