Molecularly imprinted polymer-based reusable biosensing device on stainless steel for spatially localized detection of cytokine IL-1β

Deng, Fei; Goldys, Ewa M.; Liu, Guozhen

doi:10.1016/j.snb.2019.04.142

Cited by 17 publications

(10 citation statements)

References 46 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antigen-specific detection antibodies with fluorescent tags then are applied. Using the system, Deng et al (124) developed a reusable molecular imprint polymer to detect IL-1b with a LOD of 10.2 pg/mL and could reuse the biosensing device more than three times with a coefficient of variation of 2.08%. Tao et al (125) used molecular imprint containing luminescent reporter molecules, to directly quantify the bound IL-1 from plasma using the biosensor alone which gave 2 pg/mL LOD and >95% reversibility of the platform, even after being used more than 25 times.…”

Section: Label-based Immunoassaysmentioning

confidence: 99%

“…Using the system, Deng et al. ( 124 ) developed a reusable molecular imprint polymer to detect IL-1β with a LOD of 10.2 pg/mL and could reuse the biosensing device more than three times with a coefficient of variation of 2.08%. Tao et al.…”

Section: The Established and Emerging Devices For Cytokine And Other Cancer-specific Biomarker Detections And Their Potential Technologicmentioning

confidence: 99%

See 1 more Smart Citation

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

et al. 2021

View full text Add to dashboard Cite

Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor microenvironment promotes the secretion of diverse cytokines, in different types and stages of cancers. These cytokines may inhibit tumor development but alternatively may contribute to chronic inflammation that supports tumor growth in both autocrine and paracrine manners and have been linked to poor cancer outcomes. Such distinct sets of cytokines from the tumor microenvironment can be detected in the circulation and are thus potentially useful as biomarkers to detect cancers, predict disease outcomes and manage therapeutic choices. Indeed, analyses of circulating cytokines in combination with cancer-specific biomarkers have been proposed to simplify and improve cancer detection and prognosis, especially from minimally-invasive liquid biopsies, such as blood. Additionally, the cytokine signaling signatures of the peripheral immune cells, even from patients with localized tumors, are recently found altered in cancer, and may also prove applicable as cancer biomarkers. Here we review cytokines induced by the tumor microenvironment, their roles in various stages of cancer development, and their potential use in diagnostics and prognostics. We further discuss the established and emerging diagnostic approaches that can be used to detect cancers from liquid biopsies, and additionally the technological advancement required for their use in clinical settings.

show abstract

Section: Label-based Immunoassaysmentioning

confidence: 99%

Section: The Established and Emerging Devices For Cytokine And Other Cancer-specific Biomarker Detections And Their Potential Technologicmentioning

confidence: 99%

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[ 76,77 ] Liu et al. have developed different biosensing platforms for single cytokine monitoring from in vitro to in vivo with fluorescence signal readout [ 78–84 ] or electrochemical signal readout. [ 85,86 ] In order to realize the cytokine monitoring in mouse brain or spinal cords, deployable devices based on immunosensors on optical fiber [ 87,88 ] and stainless steel [ 80,89 ] have been developed for detection of spatially localized cytokines at the levels of pg/mL.…”

Section: Current Advances In Cytokine Detection Platformsmentioning

confidence: 99%

Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges

Liu

Jiang

Lin

et al. 2021

VIEW

Self Cite

View full text Add to dashboard Cite

Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in disease severity and major‐organ damage. Thus, there is urgent need to develop rapid, sensitive, and specific methods for monitoring of cytokines in biology and medicine. Undoubtedly, point‐of‐care testing (POCT) will provide clinical significance in disease early diagnosis, management, and prevention. This review aims to summarize and discuss the latest technologies for detection of cytokines with a focus on POCT. The overview of diseases resulting from imbalanced cytokine levels, such as COVID‐19, sepsis and other cytokine release syndromes are presented. The clinical cut‐off levels of cytokine as biomarkers for different diseases are summarized. The challenges and perspectives on the development of cytokine POCT devices are also proposed and discussed. Cytokine POCT devices are expected to be the ongoing spotlight of disease management and prevention during COVID‐19 pandemic and also the post COVID‐19 pandemic era.

show abstract

“…Deng et al presented the development of a biomimetic sensor targeting Interleukin-1β (IL-1β), a cytokine protein shown to be heavily implicated in the progression of CVD and that has been suggested as a prognostic biomarker of heart failure (although its value as a useful cardiac biomarker is often disputed, primarily due to its presence in extremely low concentrations) [110,111,112,113,114,115,116]. The authors performed the surface imprinting on a stainless steel ribbon, alluding to advantages associated with its mechanical properties compared to glass or ceramics.…”

Section: Detection Techniquesmentioning

confidence: 99%

“…Detection scheme for a hybrid IL-1β biomimetic sensor [110] (Figure was re-printed with permission from the publisher).…”

Section: Figurementioning

confidence: 99%

Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease

Regan

Walsh

O’Kennedy

et al. 2019

Sensors

View full text Add to dashboard Cite

Molecular imprinting is a rapidly growing area of interest involving the synthesis of artificial recognition elements that enable the separation of analyte from a sample matrix and its determination. Traditionally, this approach can be successfully applied to small analyte (<1.5 kDa) separation/ extraction, but, more recently it is finding utility in biomimetic sensors. These sensors consist of a recognition element and a transducer similar to their biosensor counterparts, however, the fundamental distinction is that biomimetic sensors employ an artificial recognition element. Molecularly imprinted polymers (MIPs) employed as the recognition elements in biomimetic sensors contain binding sites complementary in shape and functionality to their target analyte. Despite the growing interest in molecularly imprinting techniques, the commercial adoption of this technology is yet to be widely realised for blood sample analysis. This review aims to assess the applicability of this technology for the point-of-care testing (POCT) of cardiovascular disease-related biomarkers. More specifically, molecular imprinting is critically evaluated with respect to the detection of cardiac biomarkers indicative of acute coronary syndrome (ACS), such as the cardiac troponins (cTns). The challenges associated with the synthesis of MIPs for protein detection are outlined, in addition to enhancement techniques that ultimately improve the analytical performance of biomimetic sensors. The mechanism of detection employed to convert the analyte concentration into a measurable signal in biomimetic sensors will be discussed. Furthermore, the analytical performance of these sensors will be compared with biosensors and their potential implementation within clinical settings will be considered. In addition, the most suitable application of these sensors for cardiovascular assessment will be presented.

show abstract

Molecularly imprinted polymer-based reusable biosensing device on stainless steel for spatially localized detection of cytokine IL-1β

Cited by 17 publications

References 46 publications

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges

Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease

Contact Info

Product

Resources

About