Molecularly Imprinted Polymer-Based Microfluidic Systems for Point-of-Care Applications

Saylan, Yeşeren; Deni̇zli̇, Adil

doi:10.3390/mi10110766

Cited by 30 publications

(19 citation statements)

References 67 publications

(73 reference statements)

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“…MIP-based sensors for point-of-care diagnostics is an increasing field, as MIPs can be combined with several different electrochemical transducers in a wide variety of sensor platforms [112]. Eersels et al incorporated MIPs into a thermal biomimetic sensor platform for detection of vitamin K in serum samples [90].…”

Section: Mips and Biomarkersmentioning

confidence: 99%

Molecularly Imprinted Polymers in Biological Applications

et al. 2020

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Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

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Section: Mips and Biomarkersmentioning

confidence: 99%

Molecularly Imprinted Polymers in Biological Applications

et al. 2020

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“…The molecular imprinting methods enable specific and selective molecular recognition for desired template molecules [49][50][51]. Basically, three dimensional-biomimetic cavities complementary to the template molecule in shape, size, physical, and chemical functionality can be produced by creating a matrix around the template molecules [52,53].…”

Section: Molecular Imprinting Methodsmentioning

confidence: 99%

Advances in Biomimetic Systems for Molecular Recognition and Biosensing

et al. 2020

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Understanding the fundamentals of natural design, structure, and function has pushed the limits of current knowledge and has enabled us to transfer knowledge from the bench to the market as a product. In particular, biomimicry―one of the crucial strategies in this respect―has allowed researchers to tackle major challenges in the disciplines of engineering, biology, physics, materials science, and medicine. It has an enormous impact on these fields with pivotal applications, which are not limited to the applications of biocompatible tooth implants, programmable drug delivery systems, biocompatible tissue scaffolds, organ-on-a-chip systems, wearable platforms, molecularly imprinted polymers (MIPs), and smart biosensors. Among them, MIPs provide a versatile strategy to imitate the procedure of molecular recognition precisely, creating structural fingerprint replicas of molecules for biorecognition studies. Owing to their affordability, easy-to-fabricate/use features, stability, specificity, and multiplexing capabilities, host-guest recognition systems have largely benefitted from the MIP strategy. This review article is structured with four major points: (i) determining the requirement of biomimetic systems and denoting multiple examples in this manner; (ii) introducing the molecular imprinting method and reviewing recent literature to elaborate the power and impact of MIPs on a variety of scientific and industrial fields; (iii) exemplifying the MIP-integrated systems, i.e., chromatographic systems, lab-on-a-chip systems, and sensor systems; and (iv) closing remarks.

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“…In this context, a wealth of different synthetic strategies were presented to facilitate the design of efficient, imprinted materials for the application of interest. More detailed explanations of the synthesis, application, and limitations of MIPs can be found recent reviews [ 2 , 12 , 14 , 17 , 24 , 27 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial Biomimetic Electrochemical Assemblies

et al. 2022

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Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining popularity due to their ability to design sensor platforms that are selective to determine target analytes. Naturally generated receptor units have a high affinity for their targets, which provides the selectivity of a device. However, such receptors are subject to instability under harsh environmental conditions and have consequently low durability. By applying principles of supramolecular chemistry, molecularly imprinted polymers (MIPs) can successfully replace natural receptors to circumvent these shortcomings. This review summarizes the recent achievements and analytical applications of electrosynthesized MIPs, in particular, for the detection of protein-based biomarkers. The scope of this review also includes the background behind electrochemical readouts and the origin of the gate effect in MIP-based biosensors.

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Molecularly Imprinted Polymer-Based Microfluidic Systems for Point-of-Care Applications

Cited by 30 publications

References 67 publications

Molecularly Imprinted Polymers in Biological Applications

Molecularly Imprinted Polymers in Biological Applications

Advances in Biomimetic Systems for Molecular Recognition and Biosensing

Artificial Biomimetic Electrochemical Assemblies

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