Molecularly imprinted polymer as a solid phase extractor in flow analysis

Dias, Ana Cristi Basile; Figueiredo, Eduardo Costa; Grassi, Viviane; Zagatto, Elias A.G.; Arruda, Marco Aurélio Zezzi

doi:10.1016/j.talanta.2008.05.040

Cited by 71 publications

(33 citation statements)

References 101 publications

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“…Molecularly imprinted polymers (MIPs) were mainly used in analytical fields, with applications geared toward separating, purifying, and quantifying different compounds, ranging from small drugs to therapeutic proteins. [23][24][25][26] These applications include ligand-binding immunoassays, [27] enantioseparation using liquid and electrochromatography, [28][29][30] solid-phase extraction, [31] catalysis and sensor design, as well as antibody and receptor mimicry ( Figure 5). [32] Molecular Imprinting Applied to Drug Delivery Molecular imprinting can provide an additional mechanism to control drug release, making imprinted polymers a rational step in drug delivery advancement.…”

Section: Introduction To Molecular Imprintingmentioning

confidence: 99%

Affinity‐Based Drug Delivery

Wang

Recum

2010

Macromolecular Bioscience

175

146

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Affinity-based drug delivery systems utilize interactions between the therapeutic drug and the delivery system to manipulate drug loading and to control drug release. In this paper, affinity-based drug delivery system syntheses, types of therapeutic factors delivered, and delivery system loading and release are discussed in detail. The paper is divided into three subsections, based on the type of delivery system: molecular imprinting systems, growth-factor delivery, and cyclodextrin-based delivery. The objective of this paper is to examine the current state of research, highlight the breakthroughs and challenges, point out potential impacts of this relatively new technology, and explore future developmental areas.

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Section: Introduction To Molecular Imprintingmentioning

confidence: 99%

Affinity‐Based Drug Delivery

Wang

Recum

2010

Macromolecular Bioscience

175

146

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“…Moreover, the former is practically much easier, since complex formation occurs between template and monomers in a solution. Figure 2 shows this entire process schematically and more details on the preparation of imprints can be found elsewhere (Diaz-Garcia & Lamo, 2005;Qiao et al, 2006;Dias et al, 2009). It should be stressed that some monomers have natural affinity to some herbicides (Breton et al, 2007).…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Solid-Phase Extraction for Enrichment and Separation of Herbicides

Pyrzyńska¹

2011

Herbicides, Theory and Applications

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“…This is the case of molecularly imprinted polymers (MIPs), by which polymeric materials are easily tailored with suitable selectivity for a guest compound [33,34]. There are various successful applications of MIPs, including chromatography [35,36], artificial antibodies [37][38][39], chemical sensors [40,41], and solid-phase extraction (SPE) [42,43], as well as potentiometric ionophores [44,45].…”

Section: Introductionmentioning

confidence: 99%

New molecularly-imprinted polymer for carnitine and its application as ionophore in potentiometric selective membranes

Moret¹,

Moreira²,

Almeida³

et al. 2014

Materials Science and Engineering: C

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a b s t r a c tKeywords: Carnitine Molecularly-imprinted polymer Sensor Potentiometry Urine Carnitine (CRT) is a biological metabolite found in urine that contributes in assessingseveral disease conditions, including cancer. Novel quick screening procedures for CRT are therefore fundamental. This work proposes a novel potentiometric device where molecularly imprinted polymers (MIPs) were used as ionophores. The host-tailored sites were imprinted on a polymeric network assembled by radical polymerization of methacrylic acid (MAA) and trimethylpropane trimethacrylate (TRIM). Non-imprinted polymers (NIPs) were produced as control by removing the template from the reaction media. The selective membrane was prepared by dispersing MIP or NIP particles in plasticizer and poly(vinyl chloride), PVC, and casting this mixture over a solid contact support made of graphite. The composition of the selective membrane was investigated with regard to kind/amount of sensory material (MIP or NIP), and the need for a lipophilic additive. Overall, MIP sensors with additive exhibited the best performance, with near-Nernstian response down to~1 × 10, at pH 5, and a detection limitof~8 × 10−5 mol L −1 . Suitable selectivity was found for all membranes, assessed by the matched potential method against some of the most common species in urine (urea, sodium, creatinine, sulfate, fructose and hemoglobin). CRT selective membranes including MIP materials were applied successfully to the potentiometric determination of CRT in urine samples.

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Molecularly imprinted polymer as a solid phase extractor in flow analysis

Cited by 71 publications

References 101 publications

Affinity‐Based Drug Delivery

Affinity‐Based Drug Delivery

Solid-Phase Extraction for Enrichment and Separation of Herbicides

New molecularly-imprinted polymer for carnitine and its application as ionophore in potentiometric selective membranes

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