Molecularly imprinted poly(methacrylic acid) based QCM biosensor for selective determination of L-tryptophan

Prabakaran, K.; Jandas, P.J.; Luo, Jingting; Fu, Chen; Wei, Qiuping

doi:10.1016/j.colsurfa.2020.125859

Cited by 30 publications

(14 citation statements)

References 25 publications

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“…A scheme of a QCM chip and the corresponding sensogram are shown in Scheme 2a. QCM sensors have been widely used for the detection of steroid hormones such as nandrolone [78] and neurotransmitters such as catecholamines [79], as well as for other analytes like the β-blocking drug (S)propranolol [80], caffeine [81], trichlorfon [82], α-amanitin [83], N-hexanoyl-L-homoserine lactone [84], and L-tryptophan [85]. The experimental characteristics of the sensors detecting these analytes are summarized in Table 2.…”

Section: Qcm Sensorsmentioning

confidence: 99%

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

et al. 2021

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The field of molecularly imprinted polymer (MIP)-based chemosensors has been experiencing constant growth for several decades. Since the beginning, their continuous development has been driven by the need for simple devices with optimum selectivity for the detection of various compounds in fields such as medical diagnosis, environmental and industrial monitoring, food and toxicological analysis, and, more recently, the detection of traces of explosives or their precursors. This review presents an overview of the main research efforts made so far for the development of MIP-based chemosensors, critically discusses the pros and cons, and gives perspectives for further developments in this field.

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Section: Qcm Sensorsmentioning

confidence: 99%

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

et al. 2021

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“…They optimized MIP pre-polymer solution coated on quartz crystal microbalance (QCM) electrode surface for a selective biosensing. The LOD was determined 0.73 ng mL −1 (Prabakaran et al 2021 ).…”

Section: Mip In Bioanalysismentioning

confidence: 99%

Recent molecularly imprinted polymers applications in bioanalysis

Suzaei¹,

Daryanavard

Abdel-Rehim

et al. 2022

Chem. Pap.

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Molecular imprinted polymers (MIPs) as extraordinary compounds with unique features have presented a wide range of applications and benefits to researchers. In particular when used as a sorbent in sample preparation methods for the analysis of biological samples and complex matrices. Its application in the extraction of medicinal species has attracted much attention and a growing interest. This review focus on articles and research that deals with the application of MIPs in the analysis of components such as biomarkers, drugs, hormones, blockers and inhibitors, especially in biological matrices. The studies based on MIP applications in bioanalysis and the deployment of MIPs in high-throughput settings and optimization of extraction methods are presented. A review of more than 200 articles and research works clearly shows that the superiority of MIP techniques lies in high accuracy, reproducibility, sensitivity, speed and cost effectiveness which make them suitable for clinical usage. Furthermore, this review present MIP-based extraction techniques and MIP-biosensors which are categorized on their classes based on common properties of target components. Extraction methods, studied sample matrices, target analytes, analytical techniques and their results for each study are described. Investigations indicate satisfactory results using MIP-based bioanalysis. According to the increasing number of studies on method development over the last decade, the use of MIPs in bioanalysis is growing and will further expand the scope of MIP applications for less studied samples and analytes.

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“…The QCM biosensor with AT-cut quartz has been used for the detection of various disease biomarkers found in human serum, namely the carcinoembryonic antigen (CEA); prostate-specific antigen (PSA); CD63 positive exosomes; tuberculosis biomarker; Dengue fever biomarker (non-structural protein-1 (NS1)); pancreatic disease biomarker (trypsin); hepatitis B core antigen (HBcAg); protein biomarker for malaria (PfHRP-2); and human immunodeficiency virus (HIV) biomarker (HIV-1 glycoprotein 41 (gp41), HIV-1 p24 antigen) [75,97,98,111,112,[120][121][122][123][124][125][126][127][128]. Apart from the disease biomarkers, QCM has also been used for the detection of various proteins and amino acids in human serum, such as tryptophan (Trp), immunoglobulin (IgG), hemoglobin, and plasmin (PLA), which act as early disease diagnosis markers [123,[129][130][131][132]. QCM has also been used for the study of the affinity interaction of protein biomolecules [133,134].…”

Section: (I) Proteins and Biomolecular Detectionmentioning

confidence: 99%

“…A QCM with a molecularly imprinted polymer (MIP) as a bioreceptor layer on the Au electrode has been reported for the detection of proteins and disease biomarkers in human serum, such as tryptophan (Trp) and the HIV-1 glycoprotein [124,129]. MIPs are a special type of polymer, synthesized with a cavity that specifically matches the shape, size, and functional groups of the target analytes [129]. L-Tryptophan (Trp), which is one of the essential amino acids in the human body for the development of neurotransmitters, is considered a biomarker for neurological disfunctions [138].…”

Section: (I) Proteins and Biomolecular Detectionmentioning

confidence: 99%

“…L-Tryptophan (Trp), which is one of the essential amino acids in the human body for the development of neurotransmitters, is considered a biomarker for neurological disfunctions [138]. The MIP synthesized using methacrylic acid (MAA) as a monomer with a Trp template and an ethylene glycol dimethacrylate (EGDMA) crosslinker was coated onto the Au electrode of QCM, to act as a bioreceptor for the specific and sensitive detection of Trp [129]. The device showed an LOD of 0.73 ng/mL.…”

Section: (I) Proteins and Biomolecular Detectionmentioning

confidence: 99%

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Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications

Nair

Teo

2021

Micromachines

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Lab-on-a-chip (LOC) technology has gained primary attention in the past decade, where label-free biosensors and microfluidic actuation platforms are integrated to realize such LOC devices. Among the multitude of technologies that enables the successful integration of these two features, the piezoelectric acoustic wave method is best suited for handling biological samples due to biocompatibility, label-free and non-invasive properties. In this review paper, we present a study on the use of acoustic waves generated by piezoelectric materials in the area of label-free biosensors and microfluidic actuation towards the realization of LOC and POC devices. The categorization of acoustic wave technology into the bulk acoustic wave and surface acoustic wave has been considered with the inclusion of biological sample sensing and manipulation applications. This paper presents an approach with a comprehensive study on the fundamental operating principles of acoustic waves in biosensing and microfluidic actuation, acoustic wave modes suitable for sensing and actuation, piezoelectric materials used for acoustic wave generation, fabrication methods, and challenges in the use of acoustic wave modes in biosensing. Recent developments in the past decade, in various sensing potentialities of acoustic waves in a myriad of applications, including sensing of proteins, disease biomarkers, DNA, pathogenic microorganisms, acoustofluidic manipulation, and the sorting of biological samples such as cells, have been given primary focus. An insight into the future perspectives of real-time, label-free, and portable LOC devices utilizing acoustic waves is also presented. The developments in the field of thin-film piezoelectric materials, with the possibility of integrating sensing and actuation on a single platform utilizing the reversible property of smart piezoelectric materials, provide a step forward in the realization of monolithic integrated LOC and POC devices. Finally, the present paper highlights the key benefits and challenges in terms of commercialization, in the field of acoustic wave-based biosensors and actuation platforms.

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Molecularly imprinted poly(methacrylic acid) based QCM biosensor for selective determination of L-tryptophan

Cited by 30 publications

References 25 publications

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Recent molecularly imprinted polymers applications in bioanalysis

Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications

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