Molecularly imprinted nanoparticles grafted to porous silica as chiral selectors in liquid chromatography

Gutiérrez-Climente, Raquel; Gómez‐Caballero, Alberto; Guerreiro, António; Garcia-Mutio, D.; Unceta, Nora; Goicolea, M. Aránzazu; Barrio, Ramón J.

doi:10.1016/j.chroma.2017.05.066

Cited by 32 publications

(17 citation statements)

References 34 publications

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“…Surface imprinting (polymer composite) has been proposed as an alternative to dummy templating for addressing the MIP template bleeding problem. Various materials including graphene oxide [46,47], magnetic cross-linked chitosan [48,49], silica [49,50], carbon nanotubes [51], quantum dots [52] and nanoparticles [53,54] have been used as scaffolds in the preparation of imprinted polymer composites for pharmaceutical compounds. The template is imprinted at or near the proximity of the surface, therefore, there are no deeper lying cavities that may cause slow release of template molecules and subsequently bleeding.…”

Section: Synthesis Of Polymer Compositesmentioning

confidence: 99%

Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

Madikizela¹,

Tavengwa²,

Pakade³

2018

Recent Research in Polymerization

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In this chapter, the synthetic procedures for molecularly imprinted polymers (MIPs) for pharmaceutical compounds are discussed. Regardless of its limitations, such as production of irregular particles and loss of sample during processing (crushing and sieving), bulk polymerization has been widely used compared to say precipitation and suspension polymerization partly due to its simplicity in synthesis and robustness. A comparison of indomethacin removal from aqueous solution by MIP particles prepared using bulk polymerization to those obtained from suspension polymerization showed that the particles from the former exhibited higher adsorption capacity. Furthermore, the chapter explores the strengths and limitations relating the use of pharmaceutical compounds as uni-templates, multi-templates and dummy templates. Also, the analytical applications of MIPs are discussed in more details with particular focus on molecularly imprinted solid-phase extraction (MISPE) of pharmaceuticals from environmental samples. This application (MISPE) is currently the most exploited in literature as more pharmaceutical drugs find their way into environmental water bodies.

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Section: Synthesis Of Polymer Compositesmentioning

confidence: 99%

Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

Madikizela¹,

Tavengwa²,

Pakade³

2018

Recent Research in Polymerization

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“…The main disadvantages of bulk MIP amorphous particles are poor accessibility to the target molecules (because of the large material thickness), slow mass transfer and problems with template removal. Molecular imprinting in porous silica gel microsphere surfaces exhibits several conspicuous advantages for chromatographic performance improvement due to recognition sites embedded on the surface, as well as structural rigidities and thermal stabilities [ 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase

et al. 2018

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To improve the chromatographic performance of an oseltamivir (OS) molecularly imprinted polymer (MIP), silica gel coated with an MIP layer for OS (OSMIP@silica gel) was prepared by the surface molecular imprinting technology on the supporter of porous silica gel microspheres. A nonimprinted polymer with the silica gel (NIP@silica gel) was also prepared for comparison. The obtained particles were characterized through FT–IR, scanning electron microscopy, specific surface area analysis, and porosity measurements. The results indicated that the polymer was successfully synthesized and revealed the structural differences between imprinted and nonimprinted polymers. The results of static adsorption experiments showed that adsorption quantity of the OSMIP@silica gel for OS was higher than that for NIP@silica gel, and the OSMIP@silica gel had two kinds of affinity sites for OS but the NIP@silica gel had one. The chromatographic performance of the OSMIP@silica gel column had significant improvement. The imprinting factor of the OSMIP@silica gel column for OS was 1.64. Furthermore, the OSMIP@silica gel column showed good affinity and selectivity for template OS and another neuraminidase inhibitor, peramivir, but not for quinocetone. These results indicated that the prepared OSMIP could be used to simulate the activity center of neuraminidase, and the OSMIP@silica gel column could be also employed in future studies to search for more active neuraminidase inhibitor analogues from traditional Chinese herbs.

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“…Moreover, PM-MIMs exhibit photo-responsive properties: 45.0% of 17β-E2 was released from the PM-MIMs at 365 nm irradiation, and 94.0% of the released 17β-E2 was rebound to the PM-MIMs at 440 nm. In another study, a new chiral stationary phase was improved by grafting molecularly imprinted nanoparticles (MINPs) onto silica beads [16]. Two kind of synthesis procedure, i.e.…”

Section: Molecular Imprinting Techniques For Biomimetics 21 Separatmentioning

confidence: 99%

Molecular Imprinting Technology for Biomimetic Assemblies

Bereli¹,

Akgönüllü

Aslıyüce

et al. 2020

Hacettepe Journal of Biology and Chemistry

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B iyomimetik terimi, kısaca doğanın incelenmesi olarak tanımlanabilir. Bilim adamları biyomedikal ve terapötik uygulamalarda, daha iyi ilaçlar, yapay organlar, algılama aletleri vb. yapmak için doğal modelleri, sistemleri ve unsurları taklit ederek, insan sorunlarını çözmek ve günlük yaşamı kolaylaştırmak için doğanın muazzam çeşitliliğinden ilham aldılar. Bu tür uygulamalarda, stabilite ve tekrar kullanılabilirlikteki eksikliklere rağmen, özgüllüğü sağlamak için proteinler, antikorlar, enzimler, DNA, lektinler, aptamerler, hücreler ve virüsler gibi biyolojik tanıma öğeleri yoğun olarak kullanılmıştır. Bununla birlikte, son yirmi yılda moleküler baskılanmış polimerler (MIP'ler), çapraz bağlayıcının varlığında kalıp yapı etrafında fonksiyonel monomerlerin koordine edilmesi yoluyla geniş bir örnek yelpazesi oluşturmuş ve doğal biyolojik etkileşimleri taklit etmeye bir alternatif olarak sentezlenmiştir. Bu derleme, ayırma tekniklerinde, doku mühendisliği uygulamalarında, biyomimetik yüzeylerde, sensörlerde, yapay membranlar ve ilaç taşınım sistemlerinde moleküler baskılama teknikleriyle hazırlanan biyomimetiklerin genel hatlarını ve pratik uygulamalarını özetleyecektir.

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Molecularly imprinted nanoparticles grafted to porous silica as chiral selectors in liquid chromatography

Cited by 32 publications

References 34 publications

Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase

Molecular Imprinting Technology for Biomimetic Assemblies

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