Molecularly imprinted electrochemical sensor based on bioinspired Au microflowers for ultra-trace cholesterol assay

Yang, Hua; Li, Li; Ding, Yaping; Ye, Daixin; Wang, Yingzi; Cui, Shiqiang; Liao, Lanfeng

doi:10.1016/j.bios.2016.09.081

Cited by 62 publications

(20 citation statements)

References 20 publications

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“…In this study, the bioinspired Au microflowers were formed on the surface of the electrode by wrapping AuNPs on the bioinspired polydopamine (PDA) film through electropolymerization, followed by the coating of MIP. The linear response range of this strategy was between 10 −18 and 10 −13 M, with an ultralow detection limit of 3.3 × 10 −19 M, which is more sensitive than the traditional CHO detection method (Figure 5) [93].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Applications of Gold Nanoparticles in Non-Optical Biosensors

et al. 2018

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Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

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Section: Electrochemical Biosensorsmentioning

confidence: 99%

Applications of Gold Nanoparticles in Non-Optical Biosensors

et al. 2018

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“…Indeed, different methods were used to detect and determine cholesterol such as MS spectroscopic [11,12], chromatographic [13,14], electrochemical [15][16][17][18], spectrophotometric [7,19] and fluorometric methods [20][21][22][23].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Synthesis, spectral characterization, molecular modeling, antibacterial and antioxidant activities and stability study of binuclear Pd(II) and Ru(III) complexes with novel bis-[1-(2-[(2-hydroxynaphthalen-1-yl)methylidene]amino}ethyl)-1-ethyl-3-phenylthiourea] ligand: Application to detection of cholesterol

Terbouche

Ait‐Ramdane‐Terbouche

Bendjilali

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A novel bis-[1-(2-[(2-hydroxynaphthalen-1-yl) methylidene]amino}ethyl)-1-ethyl-3-phenylthiourea] Schiff base (L) and its binuclear palladium and ruthenium complexes have been prepared and characterized by ESI-MS, elemental analysis, NMR (H NMR, C NMR, COSY, NEOSY and HSQC), FT-IR, ATR, UV-Visible spectra, TGA measurements, conductivity and cyclic voltammetry. The experimental results and the molecular parameters calculated using DFT method revealed a square planar geometry around Pd and octahedral geometry around ruthenium metal. The antibacterial activity of the ligand L and its complexes was evaluated against different human bacteria. In addition, the formation constants of the synthesized Schiff base-metal complexes and the systems formed with these chelates and cholesterol were estimated using spectrophotometric technique. The detection of cholesterol using novel Pd and Ru Schiff base complexes was studied using fluorometric method, and the measurements showed that the sensitive fluorometric response towards cholesterol analysis was determined using palladium complex. The limit of detection (LOD) of cholesterol calculated using this complex (4.6 μM) is lower (better) than LOD found using ruthenium complex (19.1 μM) and different compounds previously published around linear range of 0-5 mM.

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“…The proposed sensor offered the best LOD value of 3.3×10 −19 M reported till now and showed linear response between 10 −18 and 10 −13 M concentration of cholesterol. Such a low LOD was attributed to the effective synergistic effect of PDA, Au microflowers, DGr (DA@Graphene) and MIP …”

Section: Application Of Da As Substrate For Secondary Modificationmentioning

confidence: 99%

An Account on the Versatility of Dopamine as a Functional Monomer in Molecular Imprinting

Zaidi

2019

ChemistrySelect

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Apart from being a vital catecholamine molecule responsible for the proper functioning of central nervous system (CNS), hormonal and renal systems, dopamine (DA) has also been increasingly employed as a functional monomer in the fabrication of surface molecular imprinting of valuable analytes, especially for proteins. The application of dopamine as functional monomer was inspired from mussel adhesion protein, its capability of self-polymerization under weak alkaline aqueous solution resulting into thin biocompatible highly cross-linked polydopmaine (PDA) film and cost-effectiveness. Furthermore, it could adhere strongly on various (organic and inorganic) substrates without any attachment, and possesses plenty of noncovalent functionalities such as amino-containing groups, hydroxyl-containing groups and π-π for further modifications. In this first ever review, we focused our attention on the utilization and influence of DA as a functional monomer in the fabrication of molecular imprinting and discussed it comprehensively.[a] Prof.

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Molecularly imprinted electrochemical sensor based on bioinspired Au microflowers for ultra-trace cholesterol assay

Cited by 62 publications

References 20 publications

Applications of Gold Nanoparticles in Non-Optical Biosensors

Applications of Gold Nanoparticles in Non-Optical Biosensors

An Account on the Versatility of Dopamine as a Functional Monomer in Molecular Imprinting

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