Molecularly imprinted drug delivery systems

Cunliffe, David; Kirby, Andrew R.; Alexander, Cameron

doi:10.1016/j.addr.2005.07.015

Cited by 118 publications

(131 citation statements)

References 115 publications

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“…1e Promising applications for MIPs include chemo-sensors for blood screening; detection of explosives or chemical and biological weapons; 4 purification of natural products; 5 catalysis; 6 and as slow-release drug delivery systems. 7 It is sometimes claimed that such materials can, or at least have the potential to, exhibit almost enzyme-like selectivity, being able to distinguish very similar species. But our inability to control individual polymerization steps and determine a detailed structural view of an imprinted polymer makes any control or unambiguous demonstration of such selectivity very difficult.…”

Section: Introductionmentioning

confidence: 99%

Probing the Structural and Binding Mechanism Heterogeneity of Molecularly Imprinted Polymers

Schauperl

Lewis

2015

J. Phys. Chem. B

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ABSTRACT:We devise a strategy, using a de novo building approach, to construct model molecularly imprinted polymers (MIPs) and assess their ability at binding various target molecules. Whilst our models successfully reproduce the gross experimental selectivities for two xanthines, or atomistic models reveal in detail the considerable heterogeneity of the structure and binding mechanisms of different imprints within such a material. We also demonstrate how nonimprinted regions of a MIP are also responsible for much of binding of target molecules. High levels of crosslinking are shown to produce less specific imprints.

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Section: Introductionmentioning

confidence: 99%

Probing the Structural and Binding Mechanism Heterogeneity of Molecularly Imprinted Polymers

Schauperl

Lewis

2015

J. Phys. Chem. B

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“…The imprinted hydrogels modulate (collapse and swell) to suit the conditions where the polymer is going to be used to release its load of therapeutic agent. It has also been reported that the drug release profiles of MIP-based DDS devices were not impressive compared to other controlled polymer systems, which could have been achieved with slight modifications; nevertheless, they behave as smart feedback-controlled DDS sensing the encircling environment and trigger the drug release in overexpressing of biomarker in case of any disease (Cunliffe et al, 2005;Sellergren & Allender, 2005).…”

Section: Rationale For Mips Application In Ddsmentioning

confidence: 99%

Molecular imprinted polymers as drug delivery vehicles

Zaidi

2014

Drug Delivery

107

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This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).

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“…This technique is a very useful approach for the fabrication of a matrix with molecular recognition sites that are formed by the addition of template molecules during the matrix formation process, and for the removal of the template molecule after the matrix formation [1][2][3][4][5]. Molecularly imprinted matrixes have been developed for over a decade in many fields, such as chromatography, catalysis, artificial antibodies, and sensing devices [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Inorganic Molecularly Imprinted Polymer by Sol-Gel Process for Recognition of Caffeine

Shin¹,

Shin²,

Shin³

2013

OJOPM

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A molecularly imprinted polymer (MIP) was formed using an inorganic polymer by a sol-gel process. The monomers which were used to synthesize the inorganic polymer were tetraethoxysilane (TEOS), triethoxymethylsilane (MTES), and triethoxyphenylsilane (PTES). Caffeine was chosen as a template for the molecular imprinting, and theophylline was chosen as the analogous counterpart compound. The discriminating ability of the synthesized MIP to these twocompounds was estimated in this study. The MIP showed the highest discriminating ability when the ratio of TEOS:MTES:PTES in the synthesis of the inorganic polymer was 1:1:3, the reaction temperature was 50˚C, and the pH of the reaction system was ~6.5.

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Molecularly imprinted drug delivery systems

Cited by 118 publications

References 115 publications

Probing the Structural and Binding Mechanism Heterogeneity of Molecularly Imprinted Polymers

Probing the Structural and Binding Mechanism Heterogeneity of Molecularly Imprinted Polymers

Molecular imprinted polymers as drug delivery vehicles

Inorganic Molecularly Imprinted Polymer by Sol-Gel Process for Recognition of Caffeine

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