Molecularly imprinted composite polymers based on trimethylolpropane trimethacrylate (TRIM) particles for efficient enantiomeric separations

Glad, Magnus; Reinholdsson, Per; Mosbach, Klaus

doi:10.1016/0923-1137(95)00018-e

Cited by 84 publications

(41 citation statements)

References 27 publications

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“…1 These kinds of polymers were referred to as molecularly imprinted polymers (MIPs), which provided a means of creating specific recognition and combination similar to those in biological system such as antibodies to antigens, enzymes to zymolytes, [2][3][4] had exhibited extensive application prospects in enantiomer separation, [5][6][7] antibody binding mimic, 8 -10 enzyme mimic, 11,12 biomimic sensor, 13,14 control of equilibrium shifting of chemical reaction, 15 byproduct removal, 16 and so on. [17][18][19][20] The characterizations of molecular recognition selectivity of MIPs have not been a unified method yet for their broad application areas.…”

Section: Introductionmentioning

confidence: 99%

Protein‐imprinted soft‐wet gel composite microspheres with magnetic susceptibility. II. Characteristics

Cheng

Pang

2005

J of Applied Polymer Sci

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Protein-imprinted soft-gel composite microspheres with magnetic susceptibility (MS-PIGMs) were prepared by inverse suspension polymerization using Fe 3 O 4 particles as magnetically susceptible component and bovine serum albumin and lysozyme (Lyz) as templates, respectively. The average content of magnetically susceptible component (Fe 3 O 4 ) inside MS-PIGMs was determined using thermogravimetric analyzer, and the magnetic characteristics of MS-PIGMs were measured by vibrating sample magnetometer. The results showed that the resulting MS-PIGMs had a certain magnetic response to external magnetic fields, and their average content of Fe 3 O 4 was 2.08%. Their recognition specificity was investigated using BSA and Lyz as both templates and control molecules and characterized by high-performance liquid chromatography, and the mechanism of imprinting and recognition was analyzed. It was shown that the resulting BSA imprinted soft-gel composite microspheres with magnetic susceptibility (BSA-PIGMs) and Lyz imprinted soft-gel composite microspheres with magnetic susceptibility (Lyz-PIGMs). All exhibited good recognition selectivity for their templates, and the relative separation factor (␤) was 4.75 and 5.88, respectively. The recognition selectivity of MS-PIGMs to their templates depended mainly on the synergic action of a large quantity of hydrogen binding being caused by complementation and very close contact of outer surface of proteins with inner surface of "imprinting cavities."

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Section: Introductionmentioning

confidence: 99%

Protein‐imprinted soft‐wet gel composite microspheres with magnetic susceptibility. II. Characteristics

Cheng

Pang

2005

J of Applied Polymer Sci

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“…Este combina um éster metacrilato reactivo com um espaçador curto, permitindo um número elevado de conformações e um certo grau de rigidez no polímero resultante. 23 Apesar de os agentes de reticulação bifuncionais predominarem na maioria dos MIPs, outros monómeros tri e tetra funcionais, como o trimetilpropano trimetacrilato (TRIM), 43 o pentaeritritol triacrilato (PETRA), 44,45 e o pentaeritritol tetraacrilato (PETEA) também se apresentam adequados. 44 Sibrian-Vasquez e Spivak descreveram um aumento da capacidade de reconhecimento quiral por parte dos polí-meros preparados com novos agentes de reticulação bifuncionais, os quais se assemelham ao EGDMA, em que o grupo éster metacrilato foi substituído por metacrilamida ou por funções vinilcetona.…”

Section: Agentes De Reticulaçãounclassified

Polímeros com capacidade de reconhecimento molecular no controlo da libertação de fármacos. Parte 1: síntese e caracterização

Sousa¹,

Barbosa²

2009

Quím. Nova

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Recebido em 30/8/08; aceito em 20/1/09; publicado na web em 10/8/09MOLECULARLY IMPRINTED POLYMERS FOR CONTROLLING DRUG RELEASE. PART 1: SYNTHESIS AND CHARACTERIZATION. Molecularly imprinted polymers (MIPs) consist of synthetic macromolecular matrix, obtained through molecular imprinting-based methods that show ability to selectively recognize important biological molecules and its application in the drug delivery field is under development. In the present review the main aspects related to the synthesis and characterization of MIPs are studied. The fundamental variables participating in the synthesis process, such as template molecule, functional monomers, cross-linking agents, solvents and imprinting approaches are discussed. Moreover, the main available methods for MIPs chemical and morphological characterization are presented and the importance of the obtained information is discussed.Keywords: molecularly imprinted polymers (MIPs); imprinting approaches; MIPs characterization. INTRODUÇÃOO reconhecimento molecular é definido como a capacidade de uma molécula se ligar a outra que apresenta uma forma complementar com a primeira.1 Os polímeros com capacidade de reconhecimento molecular (designados na literatura anglo-saxónica molecularly imprinted polymers -MIPs) encontram-se actualmente bem definidos. Consistem em matrizes macromoleculares sintéticas, obtidas com base em métodos de moldagem molecular, que apresentam a capacidade de reconhecer selectivamente moléculas importantes do ponto de vista biológico, como fármacos, proteínas e biomoléculas.2-6 Com efeito, as tecnologias baseadas na moldagem molecular permitem disponibilizar sistemas poliméricos eficientes, com capacidade para reconhecer moléculas bioactivas específicas, em que a interacção depende das propriedades e da concentração da molécula-molde presente no meio circundante.O reconhecimento molecular constitui já uma ferramenta bem desenvolvida na área analítica, principalmente no que se refere à separação e quantificação de diferentes substâncias, como fármacos e moléculas bioactivas, presentes em matrizes mais ou menos complexas.7-10 Presentemente, encontram-se comercializados alguns produtos baseados nesta tecnologia.11,12 Embora estes materiais ainda não tenham alcançado uma aplicação clínica no domínio do controlo da libertação de fármacos, vários autores referem que esta tecnologia apresenta grande potencial no desenvolvimento de formas farmacêuticas mais adequadas.13-16 Outra razão que tem vindo a promover o interesse pelos MIPs reside no facto de estes poderem mimetizar receptores biológicos em estudos de desenvolvimento de novas substâncias com actividade farmacológica e também poderem detectar substâncias específicas em fluidos biológicos (como, por exemplo, nos testes de detecção de drogas de abuso).12,17 De acordo com Mosbach e Ramström, 18 esta especificidade é comparável à dos anticorpos monoclonais utilizados em técnicas imunológicas. O presente trabalho constitui uma revisão de conjunto relativa à síntese e caracterização de MIPs. No ...

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“…As to the first aspect, molecularly imprinted composite polymers were prepared using preformed poly(trimethylolpropane trimethacrylate) beads as the supporting material [14]. The residual double bonds in the supporting beads were used to graft up to 64 mol% of molecularly imprinted cross-linked polymethacrylate.…”

Section: Molecularly Imprinted Hybrid Materialsmentioning

confidence: 99%

Molecularly Imprinted Materials: Towards the Next Generation

Mosbach

2002

MRS Proc.

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This brief overview summarizes some recent developments from our Center for Molecular Imprinting related to the topic of this symposium. After a short presentation of the principle of molecular imprinting and recognition, the use of different materials including hybrids for the formation of the host will be discussed, followed by examples given of different formats used such as small polymer beads. In closing, potential directions for the next generation of molecular imprinting technology will be discussed.

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Molecularly imprinted composite polymers based on trimethylolpropane trimethacrylate (TRIM) particles for efficient enantiomeric separations

Cited by 84 publications

References 27 publications

Protein‐imprinted soft‐wet gel composite microspheres with magnetic susceptibility. II. Characteristics

Protein‐imprinted soft‐wet gel composite microspheres with magnetic susceptibility. II. Characteristics

Polímeros com capacidade de reconhecimento molecular no controlo da libertação de fármacos. Parte 1: síntese e caracterização

Molecularly Imprinted Materials: Towards the Next Generation

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