Molecularly engineered p(HEMA)-based hydrogels for implant biochip biocompatibility

Abraham, Sheena; Brahim, Sean; Ishihara, Kazuhíko; Guiseppi‐Elie, Anthony

doi:10.1016/j.biomaterials.2005.01.031

Cited by 170 publications

(136 citation statements)

References 40 publications

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“…This post-polymerization modification approach circumvents a number of problems associated with direct polymer synthesis and enables the creation of polymeric systems that are difficult if not impossible to produce otherwise [10]. Several post-polymerization modification approaches have been developed to improve the potential application of the pHEMA hydrogel in the field of biomedical fields [11]. Among them, grafting of phosphorylcholine containing moieties [12] or incorporation of poly(ethylene oxide) chains to the pHEMA back-bones have been reported to reduce protein fouling [8].…”

Section: Introductionmentioning

confidence: 99%

Poly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells

Bayramoğlu

Bitirim

Tunalı

et al. 2013

Materials Science and Engineering: C

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Keywords: Hydrogels biocompatible polymers contact angle blood cell adhesion hemolysis rat mesenchymal stem cells Copolymerization of 2-hydroxyethylmethacrylate (HEMA) with glycidylmethacrylate (GMA) in the presence of α-α′-azoisobisbutyronitrile (AIBN) resulted in the formation of hydrogel films carrying reactive epoxy groups. Thirteen kinds of different molecules with pendant \NH 2 group were used for modifications of the p(HEMA-GMA) films. The \NH 2 group served as anchor binding site for immobilization of functional groups on the hydrogel film via direct epoxy ring opening reaction. The modified hydrogel films were characterized by FTIR, and contact angle studies. In addition, mechanical properties of the hydrogel films were studied, and modified hydrogel films showed improved mechanical properties compared with the non-modified film, but they are less elastic than the non-modified film. The biological activities of these films such as platelet adhesion, red blood cells hemolysis, and swelling behavior were studied. The effect of modified hydrogel films, including \NH 2 , (using different aliphatic \CH 2 chain lengths) \CH 3 , \SO 3 H, aromatic groups with substituted \OH and \COOH groups, and amino acids were also investigated on the adhesion, morphology and survival of rat mesenchymal stem cells (MSCs). The MTT colorimetric assay reveals that the p(HEMA-GMA)-GA-AB, p(HEMA-GMA)-GA-Phe, p(HEMA-GMA)-GA-Trp, p(HEMA-GMA)-GA-Glu formulations have an excellent biocompatibility to promote the cell adhesion and growth. We anticipate that the fabricated p(HEMA-GMA) based hydrogel films with controllable surface chemistry and good stable swelling ratio may find extensive applications in future development of tissue engineering scaffold materials, and in various biotechnological areas.

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Section: Introductionmentioning

confidence: 99%

Poly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells

Bayramoğlu

Bitirim

Tunalı

et al. 2013

Materials Science and Engineering: C

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“…Recently, there has been increasing interest in the use of hydrogels for novel drug and cell delivery and also as tissue engineering scaffold. [5][6][7][8][9][10] Poly(Nvinyl pyrrolidone) (PNVP), a well-known hydrophilic polymer, has many biomedical applications such as a blood plasma extender, a carrier of drug delivery, a modifier for enzymes, and a copolymer in UV-curable bioadhesives due to its many outstanding properties and biocompatibility. 11 In addition, it † To whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Miscible Blend and Semi-IPN Gel of Poly(hydroxyethyl aspartamide) with Poly(N-vinyl pyrrolidone)

Meng¹,

Jeon²,

Chung³

et al. 2012

Polymer Korea

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PHEAs [α,β-poly(2-hydroxyethyl-DL-aspartamides)], a class of poly(amino acid), have been widely studied as biodegradable and biocompatible polymers for potential biomedical and pharmaceutical applications. In this study, we investigated a homogeneous blend of PHEA with poly(N-vinyl pyrrolidone) (PNVP) and its semi-IPN (semi-interpenetrating polymer network) gels. Blend films were prepared by a solution casting method. The resulting blends were totally transparent over the whole composition ranges and the single T g , changing monotonously with composition, was observed by DSC to confirm the miscibility between these two polymers. FTIR was used to discuss the possible hydrogen-bonding interaction between polymers. In addition, semi-IPN type gels were prepared by chemical crosslinking of PHEA/PNVP blend solution using hexamethylene diisocyanate (HMDI) as a crosslinking reagent. The prepared gel was characterized by their swelling property and morphology.

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“…Poly(ethylene oxide) (PEO) and poly(2-hydroxyethyl methacrylate) (PHEMA) are two of the most frequently investigated classes of hydrophilic polymers. PHEMA, which is currently used in contact lenses [2], biocompatibilization, and drug delivery [3], is an important hydrophilic polymer. The recent development of controlled/"living" radical polymerizations, especially atom transfer radical polymerization (ATRP), has opened a new route to synthesize functional and architectural polymers with well-defined structures [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and self-assembly of poly(ethylene oxide)-b-poly (2-hydroxyethyl methacrylate)

et al. 2009

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Poly(ethylene oxide)-b-poly(2-hydroxyethyl methacrylate) (PEO-b-PHEMA) was synthesized by successive atom transfer radical polymerization (ATRP) of 2-hydroxyethyl methacrylate（HEMA） monomer using PEO-Br macroinitiator as initiator, CuBr/CuBr 2 and 2,2"-bipyridyl (bpy) as catalyst and ligand. IR, 1 H NMR, and GPC analysis indicate that PEO-b-PHEMA block copolymer with low polydispersity index (M w /M n ≈ 1.1) has been formed. Selfassembly of this double hydrophilic block copolymer in the selective solvent and water was also studied. Owing to the high hydrophilic nature of the PEO and PHEMA blocks, this double hydrophilic block copolymer cannot disperse well in water. So block copolymer was modified by part esterification of PEO-b-PHEMA with acetic anhydride, which increased the hydrophobic group of the PHEMA block. The TEM results show that this block copolymer spontaneously form well-defined micelles in water.

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Molecularly engineered p(HEMA)-based hydrogels for implant biochip biocompatibility

Cited by 170 publications

References 40 publications

Poly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells

Poly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells

Miscible Blend and Semi-IPN Gel of Poly(hydroxyethyl aspartamide) with Poly(N-vinyl pyrrolidone)

Synthesis and self-assembly of poly(ethylene oxide)-b-poly (2-hydroxyethyl methacrylate)

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