Molecularly assembled graphdiyne with atomic sites for ultrafast and real-time detection of nitric oxide in cell assays

Graphdiyne, a carbon allotrope, was synthesized in 2010 for the first time. It consists of two acetylene bonds between adjacent benzene rings. Graphdiyne and its composites thus exhibit ultrahigh intrinsic electrochemical activities. As “star” electrode materials, they have been utilized for various electrochemical applications. With the aim of giving a full screen of graphdiyne electrochemistry, this review starts from the history of graphdiyne materials, followed by their structural and electrochemical features. Recent progress and achievements in the synthesis of graphdiyne materials and their composites are overviewed. Subsequently, various electrochemical applications of graphdiyne materials and their composites are summarized, covering those in the fields of electrochemical energy conversion, electrochemical energy storage, and electrochemical sensing. The perspectives of graphdiyne electrochemistry are also discussed and outlined.

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“…This feature facilitates high signalto-background responses of GDY materials when used in sensing applications. [42]…”

Section: Electrochemical Featuresmentioning

confidence: 99%

Graphdiyne Electrochemistry: Progress and Perspectives

Chen

Jiang

Yang

2022

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“…Gas Detection. GDY and hemin were used in a sensor with an ultra-fast nitric oxide (NO) response time [70], which was used to monitor NO released by cancer cells and normal cells in real time. The adsorption behavior and catalytic process of the active materials play an important role, where conjugated sp-hybridized C atoms with abundant electrons are expected to be favorable for promoting the interaction between NO molecules and GDY.…”

Section: Biomarker Detectionmentioning

confidence: 99%

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Jiang

et al. 2022

Cyborg Bionic Syst

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Graphdiyne (GDY) is a new member of the family of carbon-based nanomaterials with hybridized carbon atoms of sp and sp2, including α, β, γ, and (6,6,12)-GDY, which differ in their percentage of acetylene bonds. The unique structure of GDY provides many attractive features, such as uniformly distributed pores, highly π-conjugated structure, high thermal stability, low toxicity, biodegradability, large specific surface area, tunable electrical conductivity, and remarkable thermal conductivity. Therefore, GDY is widely used in energy storage, catalysis, and energy fields, in addition to biomedical fields, such as biosensing, cancer therapy, drug delivery, radiation protection, and tissue engineering. In this review, we first discuss the synthesis of GDY with different shapes, including nanotubes, nanowires, nanowalls, and nanosheets. Second, we present the research progress in the biomedical field in recent years, along with the biodegradability and biocompatibility of GDY based on the existing literature. Subsequently, we present recent research results on the use of nanomaterials in peripheral nerve regeneration (PNR). Based on the wide application of nanomaterials in PNR and the remarkable properties of GDY, we predict the prospects and current challenges of GDY-based materials for PNR.

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“…Hu et al presented a sensor based on a cocoon-derived layered carbon fiber network fabricated with iron porphyrins of heme chloride, which achieves high sensitivity and selectivity in detecting NO molecules released from living cells cultured on its surface . Hao et al combined the highly π-conjugated GDY (graphdiyne) with HEM (coordination complex of hemin) as a novel material for in vivo NO detection with a low detection limit of 7 nM and a long linear range of 151.38 μM . Li et al reported a flexible and biodegradable sensor for NO detection of single and multiple cells, which exhibits a detection limit of 3.97 nM, a long linear concentration range of 0.01 to 100 μM, and outstanding anti-interference properties.…”

Section: Introductionmentioning

confidence: 99%

“…19 Hao et al combined the highly π-conjugated GDY (graphdiyne) with HEM (coordination complex of hemin) as a novel material for in vivo NO detection with a low detection limit of 7 nM and a long linear range of 151.38 μM. 20 Li et al reported a flexible and biodegradable sensor for NO detection of single and multiple cells, which exhibits a detection limit of 3.97 nM, a long linear concentration range of 0.01 to 100 μM, and outstanding antiinterference properties. The sensor further connected with a wireless circuit to realize the detection of NO molecules in living mammals.…”

Section: Introductionmentioning

confidence: 99%

Nanoporous Ce-Based Metal–Organic Framework Nanoparticles for NO Sensing

Wang

Yin

Rao

et al. 2022

ACS Appl. Nano Mater.

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As a typical reactive nitrogen species, nitric oxide (NO) regulates various physiological processes in tissues. It is challenging to meet the requirements of low detection limit (a few nM) and wide detection range (larger than 1 μM) in detecting NO released from living cells. Herein, we prepare a nanoscale Ce-based metal–organic framework (CeMOF) biomimetic NO sensor, which obtains a high sensitivity (3.10 μA–1 μM–1 cm–2), a long detection range (6.00 nM to 312.67 μM), and a low detection limit (2.00 nM). Further, a CeMOF nanoparticle (NP) screen-printed electrode (SPE) chip is fabricated for cell adhesion and culture. By culturing cells on the surface, the CeMOF NPs/SPE achieves monitoring of NO molecules released from living HeLa and 293A cells. The Michaelis–Menten constant (K m) of the CeMOF biomimetic NO sensor is 1.3 nM, which indicates its excellent catalytic activity, which can be ascribed to the Ce coordination in CeMOF NPs to create high-density active catalytic centers for NO oxidation.

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Molecularly assembled graphdiyne with atomic sites for ultrafast and real-time detection of nitric oxide in cell assays

Cited by 21 publications

References 47 publications

Graphdiyne Electrochemistry: Progress and Perspectives

Graphdiyne Electrochemistry: Progress and Perspectives

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Nanoporous Ce-Based Metal–Organic Framework Nanoparticles for NO Sensing

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