Molecular Weight Dependence of Polymer Chain Mobility within Multilayer Films

Xu, Li; Selin, Victor; Zhuk, Aliaksandr; Ankner, John F.; Sukhishvili, Svetlana A.

doi:10.1021/mz400413v

Cited by 96 publications

(85 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found electrostatic LBL films can be smoothed via a brief annealing in high salt concentration solutions . Besides ionic strength, chain mobility in electrostatic LBL films may also be affected by solution pH, type of salt, temperature, charge density, and molecular weight of the polyelectrolytes . Rubner et al found a brief immersion of PAA/poly(allylamine) (PAH) films in acidic solution results in a substantial and irreversible transformation of the film morphology.…”

Section: Dynamic Properties Of Dynamic Lbl Filmsmentioning

confidence: 99%

Dynamically bonded layer‐by‐layer films: Dynamic properties and applications

Guan

Zhang

2014

J of Applied Polymer Sci

View full text Add to dashboard Cite

Layer-by-layer (LBL) assembly, a simple but versatile method for thin film fabrication, has been widely employed to fabricate nanoengineered films with controlled composition and thickness. Dynamically bonded LBL films are films fabricated using dynamic bonds, that is, chemical bonds which can undergo reversible breaking and reformation usually under equilibrium conditions, as driving forces. Because of the reversible, dynamic nature of the dynamic bonds, these films exhibit various dynamic properties, ranging from a small scale movement of the polymer chains within the films (chain rearrangement), to a large scale movement of the chains, which results in film disintegration. Usually an external stimulus is used to trigger the response of a dynamic film. Novel applications have been proposed by exploiting the dynamic properties of these films. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014, 131, 40918.

show abstract

Section: Dynamic Properties Of Dynamic Lbl Filmsmentioning

confidence: 99%

Dynamically bonded layer‐by‐layer films: Dynamic properties and applications

Guan

Zhang

2014

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…This cross-shell diffusion, however, is severely hampered after the formation of asolid shell, as the polyelectrolytes not only experience the steric hindrance from the porous shell but are also subjected to attractive electrostatic interactions. [12] Consequently,the shell thickness of the microcapsules is nearly independent of the concentration of the polyelectrolytes.…”

Section: Angewandte Chemiementioning

confidence: 99%

“…This independence of the shell thickness on polyelectrolyte concentration is consistent with previous reports on PE microcapsules fabricated using water-in-oil emulsions as templates, [5a] but in striking contrast to microcapsules generated by conventional double-emulsion templating methods,i nw hich the shell is formed by chemically crosslinking polymers and the shell thickness increases with the polymer concentration. [12] Consequently,the shell thickness of the microcapsules is nearly independent of the concentration of the polyelectrolytes. This cross-shell diffusion, however, is severely hampered after the formation of asolid shell, as the polyelectrolytes not only experience the steric hindrance from the porous shell but are also subjected to attractive electrostatic interactions.…”

mentioning

confidence: 99%

One‐Step Microfluidic Fabrication of Polyelectrolyte Microcapsules in Aqueous Conditions for Protein Release

et al. 2016

View full text Add to dashboard Cite

We report am icrofluidic approach for one-step fabrication of polyelectrolyte microcapsules in aqueous conditions.U sing two immiscible aqueous polymer solutions,w e generate transient water-in-water-in-water double emulsion droplets and use them as templates to fabricate polyelectrolyte microcapsules.T he capsule shell is formed by the complexation of oppositely charged polyelectrolytes at the immiscible interface.W ef ind that attractive electrostatic interactions can significantly prolong the release of charged molecules.M oreover,wedemonstrate the application of these microcapsules in encapsulation and release of proteins without impairing their biological activities.Our platform should benefit awide range of applications that require encapsulation and sustained release of molecules in aqueous environments.

show abstract

“…The lack of backpack release may originate from the increased diffusion of PAH through the film, since low molecular weight polymers tend to diffuse more quickly through multilayers than higher molecular weight polymers. 42,43 Reproducibility of the releasable backpacks was tested with films assembled using BSM from another provider (Calbiochem), to account for variations between mucin sources. A solution of 100 mM melibiose in PBS triggered release for an 80 BL film from this BSM provider, demonstrating that this methodology is applicable to various mucin sources ( Figure S5).…”

Section: 2 (Bsm/jac) Films Withstand Ph and Ionic Strength Variatiomentioning

confidence: 99%

Sugar-Mediated Disassembly of Mucin/Lectin Multilayers and Their Use as pH-Tolerant, On-Demand Sacrificial Layers

et al. 2014

View full text Add to dashboard Cite

The layer-by-layer (LbL) assembly of thin films on surfaces has proven to be an extremely useful technology for uses ranging from optics to biomedical applications. Releasing these films from the substrate to generate so-called free-standing multilayer films opens a new set of applications. Current approaches to generating such materials are limited because they can be cytotoxic, difficult to scale up, or have undesirable side reactions on the material. In this work, a new sacrificial thin film system capable of chemically triggered dissolution at physiological pH of 7.4 is described. The film was created through LbL assembly of bovine submaxillary mucin (BSM) and the lectin jacalin (JAC) for a (BSM/JAC) multilayer system, which remains stable over a wide pH range (pH 3-9) and at high ionic strength (up to 5 M NaCl). This stability allows for subsequent LbL assembly of additional films in a variety of conditions, which could be released from the substrate by incubation in the presence of a competitive inhibitor sugar, melibiose, which selectively disassembles the (BSM/JAC) section of the film. This novel multilayer system was then applied to generate free-standing, 7 μm diameter, circular ultrathin films, which can be attached to a cell surface as a "backpack". A critical thickness of about 100 nm for the (BSM/JAC) film was required to release the backpacks from the glass substrate, after incubation in melibiose solution at 37 °C for 1 h. Upon their release, backpacks were subsequently attached to murine monocytes without cytotoxicity, thereby demonstrating the compatibility of this mucin-based release system with living cells.

show abstract

Molecular Weight Dependence of Polymer Chain Mobility within Multilayer Films

Cited by 96 publications

References 32 publications

Dynamically bonded layer‐by‐layer films: Dynamic properties and applications

Dynamically bonded layer‐by‐layer films: Dynamic properties and applications

One‐Step Microfluidic Fabrication of Polyelectrolyte Microcapsules in Aqueous Conditions for Protein Release

Sugar-Mediated Disassembly of Mucin/Lectin Multilayers and Their Use as pH-Tolerant, On-Demand Sacrificial Layers

Contact Info

Product

Resources

About