Molecular virulence mechanisms of the fish pathogen Yersinia ruckeri

Fernández, Lucía; Méndez, Jessica; Guijarro, José A.

doi:10.1016/j.vetmic.2007.06.013

Cited by 67 publications

(57 citation statements)

References 42 publications

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“…Studies on DNA relatedness indicated distant relationships to both Serratia and Yersinia, and a designation into the genus Yersinia was based on similarity in biochemical reactions as well as the GC content (Sulakvelidze, 2000;Fernández, Méndez and Guijarro, 2007).…”

Section: The Special Case Of Yersinia Ruckerimentioning

confidence: 99%

“…ruckeri causes redmouth disease in salmonid fish, especially in rainbow trout, which presents as acute or chronic septicaemia with internal and external haemorrhages (Tobback, et al, 2009). Y. ruckeri has also been implicated in fatal septicaemia in carp (Sulakvelidze, 2000;Fernández, Méndez and Guijarro, 2007). As such, it is considered an important economic factor in the fish industry (Tobback, et al, 2009;Ryckaert, et al, 2010).…”

Section: The Special Case Of Yersinia Ruckerimentioning

confidence: 99%

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Evolutionary Dynamics of the Yersinia enterocolitica Complex

Reuter

Thomson

McNally

2012

Advances in Yersinia Research

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Section: The Special Case Of Yersinia Ruckerimentioning

confidence: 99%

Section: The Special Case Of Yersinia Ruckerimentioning

confidence: 99%

Evolutionary Dynamics of the Yersinia enterocolitica Complex

Reuter

Thomson

McNally

2012

Advances in Yersinia Research

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“…Infection may result in asepticaemic condition with haemorrhages on body surface and in internal organs (29). The specific pathogenic mechanisms of this bacterium have remained elusive until recently, when the results obtained with traditional microbiology have been complemented with those provided by molecular biology (8). Very little information is available on the pathogenesis hampering the development of preventive measures to efficiently combat this bacterial agent (29).…”

Section: Introductionmentioning

confidence: 99%

“…The data obtained by using novel techniques have started to shed light on the virulence of this pathogen. Iron acquisition by the siderophore ruckerbactin, proteolytic, and haemolytic activities, and resistance to immune mechanisms, were proved to be involved in the virulence of this bacterium (8).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and antioxidant defence markers in muscle tissue of rainbow trout (Oncorhynchus mykiss) after vaccination against Yersinia ruckeri

Tkachenko

Grudniewska

Pękała

et al. 2016

Journal of Veterinary Research

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Introduction: The goal of this study was to assess the influence of vaccination against enteric redmouth disease on oxidative stress biomarkers and antioxidant defence in the muscle tissue of rainbow trout (Oncorhynchus mykiss Walbaum) vaccinated against Yersinia ruckeri in the first and second month after immunisation. Material and Methods: Healthy fish were vaccinated orally with inactivated whole cells of a virulent strain of Y. ruckeri. One and two months after immunisation the muscle samples were collected. Results: No significant difference was noted in lipid peroxidation level in either the first or second month after vaccination, while aldehydic and ketonic derivatives of oxidatively modified proteins (OMB) in the vaccinated group were significantly lower in the second month compared to those in the first month after vaccination (P < 0.05). The content of ketonic derivatives of OMB in muscles in the first month after immunisation was higher compared to untreated control. All these culminated in a depletion of glutathione peroxidase (GPx) activity and low level of total antioxidant capacity (TAC). Conclusion: Correlations between catalase activity and lipid peroxidation and TAC confirmed the pivotal role of catalase in antioxidant defence during immunisation. From a broader perspective, it is suggested that immunisation of fish with Yersinia vaccine is associated with induced free radical formation and oxidative stress. Free radicals would therefore be at least partially responsible for the induction of both humoral and cellular elements of the immunity and increased protective immunity against Y. ruckeri infection.

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“…Siderophores have been used to develop vaccines and have been covered extensively (80)(81)(82)(83)(84). Bergeron and colleagues reported the use of a vibriobactin analogue linked to either ovalbumin (OVA) or bovine serum albumin (BSA) and their ability to promote antibody production in mice (85).…”

Section: Pharmacological and Medical Applicationsmentioning

confidence: 99%

Biotechnology of siderophores in high-impact scientific fields

Serrano

2017

Biomolecular Concepts

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Different aspects of bacterial and fungal siderophore biotechnological applications will be discussed. Areas of application presented include, but are not limited to agriculture, medicine, pharmacology, bioremediation, biodegradation and food industry. In agriculture-related applications, siderophores could be employed to enhance plant growth due to their uptake by rhizobia. Siderophores hindered the presence of plant pathogens in biocontrol strategies. Bioremediation studies on siderophores discuss mostly the mobilization of heavy metals and radionuclides; the emulsifying effects of siderophoreproducing microorganisms in oil-contaminated environments are also presented. The different applications found in literature based in medicine and pharmacological approaches range from iron overload to drug delivery systems and, more recently, vaccines. Additional research should be done in siderophore production and their metabolic relevance to have a deeper understanding for future biotechnological advances.

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Molecular virulence mechanisms of the fish pathogen Yersinia ruckeri

Cited by 67 publications

References 42 publications

Evolutionary Dynamics of the Yersinia enterocolitica Complex

Evolutionary Dynamics of the Yersinia enterocolitica Complex

Oxidative stress and antioxidant defence markers in muscle tissue of rainbow trout (Oncorhynchus mykiss) after vaccination against Yersinia ruckeri

Biotechnology of siderophores in high-impact scientific fields

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