Molecular typing of adenoviruses in pediatric respiratory infections in Buenos Aires, Argentina (1999–2010)

Barrero, Paola Roxana; Valinotto, Laura; Tittarelli, Estefanía; Mistchenko, Alicia

doi:10.1016/j.jcv.2011.11.001

Cited by 58 publications

(56 citation statements)

References 30 publications

(27 reference statements)

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“…In Brazil, samples collected from pediatric patients with ILI or SARI (<5 years old) demonstrated a broad range of proportions containing HAdv: 6.8% (23/336) in São Paulo [39], 6.0% (52/862) in Rio Grande do Sul [40], and 2.3% (11/482) in Salvador, Bahia [41]. Among samples only from children with SARI, proportions of HAdv ranged between: 2.8% (28/1002) from 1984 to 1987 [42] and 1.9% (916/48544) from 1999 to 2010 [43] in Argentina; 9.3% (457/4927) from 1989 to 2001 in Chile [44], and 7.0% (9/128) from 1996 to 1997 [45] and 6.2% (2/32) from 2006 to 2007 [46] in Cuba.…”

Section: Discussionmentioning

confidence: 95%

Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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BackgroundCurrently, there is a paucity of data regarding human adenovirus (HAdv) circulation in Andean regions of South America. To address this shortcoming, we report the clinical, phylogenetic, and epidemiologic characteristics of HAdv respiratory tract infection from a large sentinel surveillance study conducted among adults and children in Peru.Methods/Principal FindingsOropharyngeal swabs were collected from participants visiting any of 38 participating health centers, and viral pathogens were identified by immunofluorescence assay in cell culture. In addition, molecular characterization was performed on 226 randomly selected HAdv samples. Between 2000 and 2010, a total of 26,375 participants with influenza-like illness (ILI) or severe acute respiratory infection (SARI) were enrolled in the study. HAdv infection was identified in 2.5% of cases and represented 6.2% of all viral pathogens. Co-infection with a heterologous virus was found in 15.5% of HAdv cases. HAdv infection was largely confined to children under the age of 15, representing 88.6% of HAdv cases identified. No clinical characteristics were found to significantly distinguish HAdv infection from other respiratory viruses. Geographically, HAdv infections were more common in sites from the arid coastal regions than in the jungle or highland regions. Co-circulation of subgroups B and C was observed each year between 2006 and 2010, but no clear seasonal patterns of transmission were detected.Conclusions/SignificanceHAdv accounted for a significant fraction of those presenting with ILI and SARI in Peru and tended to affect the younger population disproportionately. Longitudinal studies will help better characterize the clinical course of patients with HAdv in Peru, as well as determine the role of co-infections in the evolution of illness.

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Section: Discussionmentioning

confidence: 95%

Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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“…Transmission of new strains across continents may occur and lead to replacement of hitherto dominant HAdV types (61). The adenoviruses most commonly reported to be associated with human disease worldwide are HAdV-C1, -C2, -C5, -B3, -B7, -B21, -E4, and -F41 (20,(62)(63)(64)(65)(66). In immunocompromised patients in the transplant setting, some of the most commonly reported adenovirus types include HAdV-C1, -C2, -C5, -A12, -A31, -B3, -B11, -B16, -B34, and -B35, with a strong predominance of species C in most instances (67)(68)(69)(70).…”

Section: Prevalence Of Hadv Species and Typesmentioning

confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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SUMMARY Human adenoviruses (HAdVs) are an important cause of infections in both immunocompetent and immunocompromised individuals, and they continue to provide clinical challenges pertaining to diagnostics and treatment. The growing number of HAdV types identified by genomic analysis, as well as the improved understanding of the sites of viral persistence and reactivation, requires continuous adaptions of diagnostic approaches to facilitate timely detection and monitoring of HAdV infections. In view of the clinical relevance of life-threatening HAdV diseases in the immunocompromised setting, there is an urgent need for highly effective treatment modalities lacking major side effects. The present review summarizes the recent progress in the understanding and management of HAdV infections.

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“…The specific Ct values calculated with our laboratory-based assays are not directly equivalent to those obtained with other PCR assays, but this concept should be applicable to other semiquantitative PCR assays. 22,23 We were unable to confirm that of all the patients who were considered to have adenovirus disease were free of CAAs on follow-up.…”

Section: Discussionmentioning

confidence: 86%