Molecular Tracing of the Global Hepatitis C Virus Epidemic Predicts Regional Patterns of Hepatocellular Carcinoma Mortality

Tanaka, Yasuhito; Kurbanov, Fuat; Mano, Shuhei; Orito, Etsuro; Vargas, Vı́ctor; Esteban, Juan Ignacio; Yuen, Man‐Fung; Lai, Ching–Lung; Kramvis, Anna; Kew, Michael C.; Smuts, Heidi; Нетесов, С. В.; Alter, Harvey J.; Mizokami, Masashi

doi:10.1053/j.gastro.2006.01.032

Cited by 105 publications

(90 citation statements)

References 46 publications

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“…Lifetime relative risk for HCC is 15-20 among HB surface antigen (sAg)-positive individuals, compared with the HBsAg-negative population [3]. HCV infection is associated with a 15-to 20-fold increase in risk for HCC compared with HCV-negative subjects in cross-sectional and case-control studies [4]. If hepatitis viruses are not cleared in the acute phase of infection, the liver may develop chronic hepatitis, in which chronic liver damage causes fibrosis, characterized by extracellular matrix (ECM) protein accumulation [5].…”

Section: Introductionmentioning

confidence: 99%

TGF-β signal shifting between tumor suppression and fibro-carcinogenesis in human chronic liver diseases

2013

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Section: Introductionmentioning

confidence: 99%

TGF-β signal shifting between tumor suppression and fibro-carcinogenesis in human chronic liver diseases

2013

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“…Due to the fact that HCV was identified in 1989 and the blood-screening programs started in the 1990's, there is limited data on HCV epidemiology and geographical distribution of its genotypes prior to this time. Tanaka et al in 2006, used the coalescent theory to investigate the past population dynamic of some HCV subtypes sampled from various countries including subtype 6a from Hong Kong. They showed that the exponential growth of HCV6a population in Hong Kong occurred in the late 1970's (20).…”

Section: Discussionmentioning

confidence: 99%

“…Tanaka et al in 2006, used the coalescent theory to investigate the past population dynamic of some HCV subtypes sampled from various countries including subtype 6a from Hong Kong. They showed that the exponential growth of HCV6a population in Hong Kong occurred in the late 1970's (20). Although the patient travelled to the United States in 2010, he has not articulated any high-risk exposure to any infectious sources of HCV during his trip.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C Virus Subtype 6a Infection in an Iranian Patient: A Case Report

Moghadam

Mohebbi

Hosseini

et al. 2013

Jundishapur J Microbiol

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Hepatitis C virus (HCV) isolates have been divided into six major genotypes, each of them further divided into several subtypes. Previous studies have shown that the most frequent genotype in Iranian patients with HCV infection is 1a, followed by 3a, 1b and 4. Infections with genotype 6 isolates have not previously been observed in these patients. In this report, we will describe the first diagnosis of HCV genotype-6 infection in Iran. The case was a 62-year-old man with positive anti-HCV antibody. Alanine aminotransferase and aspartate aminotransferase levels were 14 and 32 IU/L respectively. Viral RNA was extracted from plasma. HCV RNA level was determined using real-time reverse transcription polymerase chain reaction (PCR). Following the synthesis of the complementary DNA, 5'-UTR/core region of the HCV genome was amplified and subjected to direct sequencing. Genetic distances were estimated and phylogenetic tree was constructed. HCV viral load was 9,572,718 IU/mL. The mean inter-genotypic distance between the case sequence and the corresponding sequences of other genotype 6 isolates was 3.7%. In the phylogenetic tree, the 5'-UTR/core sequence of the subject was located in a cluster representing HCV subtype 6a. The patient was infected with HCV subtype 6a. Prior to this case, there have been no previous reports on the isolation of this genotype/subtype from any other Iranian patient. Previous epidemiological studies provide valuable information about the distribution patterns of different HCV genotypes. However, infection with genotypes other than common ones should be flagged by specialists and diagnostic laboratories, especially in patients with high-risk behavioral backgrounds.

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“…Diseases associated with increased frequencies of carriers are more prevalent among males. (Chakravarti et al, 2005 andTanaka et al, 2006).…”

Section: Clinical Sample Distribution According To Gendermentioning

confidence: 99%

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2018

Int. J. Curr. Res. Biosci. Plant Biol.

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This study was conducted to detect the prevalence of Hepatitis C virus and Hepatitis B virus of infected Patients. The study was carried out in the period from January (2016) to December (2016). The study included 420 hepatitis C and B virus suspected patients from Al-Hakeem Hospital, AL-Sader Hospital and Middle Euphrates Hospital in AlNajaf Province with gender and age ranged from (<10-70) years old from both sexes. Patients group was found to be 120 patients infected with Hepatitis represented47 Hepatitis C and 73 Hepatitis B the results of the study showed that the highest rate of infection was in HBV. Our study found the male infected with hepatitis(70.7%) and female infected with hepatitis (29.2%) so the male more infection for hepatitis then female, also we found the patients children under <10 years less infected with hepatitis and more age infected with hepatitis 20-29 and followed by age30-39 and 40-49.

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Molecular Tracing of the Global Hepatitis C Virus Epidemic Predicts Regional Patterns of Hepatocellular Carcinoma Mortality

Cited by 105 publications

References 46 publications

TGF-β signal shifting between tumor suppression and fibro-carcinogenesis in human chronic liver diseases

TGF-β signal shifting between tumor suppression and fibro-carcinogenesis in human chronic liver diseases

Hepatitis C Virus Subtype 6a Infection in an Iranian Patient: A Case Report

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