Molecular topography of an entire nervous system

Taylor, Seth R.; Santpere, Gabriel; Weinreb, Alexis; Barrett, Alec; Reilly, Molly; Xu, Chuan; Varol, Erdem; Oikonomou, Panos; Glenwinkel, Lori; McWhirter, Rebecca; Poff, Abigail; Basavaraju, Manasa; Rafi, Ibnul; Yemini, Eviatar; Cook, Steven J.; Abrams, A. Jeanine; Vidal, Berta; Cros, Cyril; Tavazoie, Saeed; Šestan, Nenad; Hammarlund, Marc; Hobert, Oliver; Miller, David M.

doi:10.1016/j.cell.2021.06.023

Cited by 442 publications

(669 citation statements)

References 135 publications

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“…Other large transcription factor families do not show such sensory neuron enrichment (Figures 1D and S1F). 14 Previous reporter analysis, 8,15 as well as the new transcriptome atlas of the entire C. elegans nervous system, 14 show that many individual sensory neurons coexpress >100 GPCRencoding genes (Figures 1C and 1D). Intriguingly, there is again a correlation of the number of nhr genes expressed by a sensory neuron with the number of GPCR-encoding genes (Figure 1C).…”

Section: Resultsmentioning

confidence: 93%

“…This notion is further strengthened by a recently established scRNA-based gene-expression atlas of the entire C. elegans nervous system, which shows a striking enrichment of nhr gene expression in sensory neurons. 14 Many sensory neurons co-express several dozens, some almost 100 nhr genes (Figures 1C and 1D). Some nhr genes are uniquely expressed in single sensory neuron classes, but 46 nhrs are expressed in more than 20 sensory neuron classes.…”

Section: Resultsmentioning

confidence: 99%

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Nematode nuclear receptors as integrators of sensory information

Sural

Hobert

2021

Current Biology

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Nematode nuclear receptors as integrators of sensory information

Sural

Hobert

2021

Current Biology

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“…L-type VGCC has been found to function in the electrosensory organs in the shark and skate, but not N-type, suggesting that C. elegans utilizes similar but different molecular mechanisms. Since EGL-19 is expressed in most if not all the neurons (Lee et al, 1997;Taylor et al, 2021), it will be interesting to identify the neurons in which the channel functions, whether they are the same or different from the neurons that utilize the N-type channels, and how they contribute to the increase in the movement speed. As mentioned above, various organs in different animal species are known to sense electric stimuli.…”

Section: Response To Electric Stimulus and Its Mechanisms In C Elegans And Other Animal Speciesmentioning

confidence: 99%

Electric shock causes a fear-like persistent behavioral response in the nematode Caenorhabditis elegans

Tee

Young

Suzuki

et al. 2021

Preprint

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Electricity is widely utilized as environmental stimulus to sense the world by many animal species. Despite its importance, however, molecular and physiological mechanisms for responding to electrical stimulus have been far less understood compared to other sensory stimuli. Here we report novel behavioral responses to electrical stimulus of the nematode C. elegans. When the animals on food are stimulated by alternating current, their movement speed suddenly increases more than 2-fold, which persists for a few minutes even after the electrical stimulation is terminated. Genetic analyses reveal that voltage-gated channels are required for the response, possibly as the sensors, and neuropeptide signaling suppresses the persistent response. Additional behavioral analysis reveals that, in addition to the persistence, the animal's response to electrical shock is scalable and has a negative valence, which are recently regarded as emotion primitives, suggesting that the response may reflect a primitive form of "fear" of animals.

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“…In addition to understanding the developmental trajectory, position and function of individual neurons, C. elegans is the only animal with a completely mapped connectome-a map of synaptic connections between neurons (White et al, 1986;Jarrell et al, 2012;Cook et al, 2019). The transcriptome of almost all neurons has also been measured at several developmental stages (Cao et al, 2017;Packer et al, 2019;Taylor et al, 2021). These data allow the gene expression profile and the function of specific neurons to be linked, providing an unparalleled opportunity for understanding the molecular mechanisms that control behavior at single cell resolution.…”

Section: Introductionmentioning

confidence: 99%

“…Here, we review the function of TFs in C. elegans behavior. Recent genomics data reveal that many hundreds of TFs are expressed in neurons (Cao et al, 2017;Packer et al, 2019;Taylor et al, 2021). However, most of these have yet to be studied in relation to neuron function and behavior and so will not be discussed here.…”

Section: Introductionmentioning

confidence: 99%

Transcription Factors That Control Behavior—Lessons From C. elegans

2021

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Behavior encompasses the physical and chemical response to external and internal stimuli. Neurons, each with their own specific molecular identities, act in concert to perceive and relay these stimuli to drive behavior. Generating behavioral responses requires neurons that have the correct morphological, synaptic, and molecular identities. Transcription factors drive the specific gene expression patterns that define these identities, controlling almost every phenomenon in a cell from development to homeostasis. Therefore, transcription factors play an important role in generating and regulating behavior. Here, we describe the transcription factors, the pathways they regulate, and the neurons that drive chemosensation, mechanosensation, thermosensation, osmolarity sensing, complex, and sex-specific behaviors in the animal model Caenorhabditis elegans. We also discuss the current limitations in our knowledge, particularly our minimal understanding of how transcription factors contribute to the adaptive behavioral responses that are necessary for organismal survival.

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Molecular topography of an entire nervous system

Cited by 442 publications

References 135 publications

Nematode nuclear receptors as integrators of sensory information

Nematode nuclear receptors as integrators of sensory information

Electric shock causes a fear-like persistent behavioral response in the nematode Caenorhabditis elegans

Transcription Factors That Control Behavior—Lessons From C. elegans

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