“…Additionally, they can also acquire resistance genes via horizontal gene transfer. QAC resistance genes can be encoded on the chromosome ( emrE, mdfA, sugE, ydgE, ydgF ) or MGEs ( oqxA, oqxB, qacEΔ1, qacE, qacF/H/I, qacG, sugE ) such as plasmids, integrons, transposons, and integrative conjugative elements [ 21 , 23 , 24 , 25 ]. Proteins involved in QAC resistance belong to the small multidrug resistance (SMR) efflux family, with the exception of MdfA, a member of the major facilitator superfamily (MFS), and OqxAB from the resistance-nodulation-division (RND) family.…”