Molecular (ticks) and serological (humans) study of Crimean-Congo hemorrhagic fever virus in the Iberian Peninsula, 2013–2015

Palomar, Ana M.; Portillo, Aránzazu; Santibáñez, Sonia; García‐Álvarez, Lara; Muñoz-Sanz, Agustín; Márquez, Francisco José Salcini; Romero, Lourdes; Eirós, José María; Oteo, José A.

doi:10.1016/j.eimce.2017.01.034

Cited by 4 publications

(6 citation statements)

References 16 publications

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“…This finding shows negative results regardless of whether the exposure risk of the area of residence was low (95% CI: 0.00–0.35), moderate (95% CI: 0.00–1.82) or high (95% CI: 0.00–2.56). In this line, a very low or null CCHFV seroprevalence was also shown in recent studies carried out in Spain (Monsalve‐Arteaga et al., 2020; Palomar et al., 2017). The survey carried out by Palomar et al.…”

Section: Resultssupporting

confidence: 79%

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The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

Frías

Cuadrado‐Matías

Jarilla‐Fernandez

et al. 2022

Transbounding Emerging Dis

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The objective of this study was to evaluate the spatial risk of exposure to Crimean-Congo haemorrhagic fever virus (CCHFV) infection of healthy blood donors in an enzootic region with a predicted risk gradient based on a virus-animal interaction risk model. We designed a cross-sectional study to test if the exposure pattern of the human population to CCHFV spatially matches the predicted risk. We randomly selected 1384 donors from different risk gradients and analyzed their sera searching for CCHFV antibodies. None of the selected blood donors showed exposure to CCHFV.This study shows that exposure risk spatial patterns, as predicted from animal-tickvirus models, does not necessarily match the pattern of human-infected tick interactions leading to CCHFV infection and CCHF cases, at least in a region of predicted moderate infection risk. The findings suggest that future studies should bear the potential drivers of tick-human encounter rates into account to more accurately predict risks.

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Section: Resultssupporting

confidence: 79%

“…The survey carried out by Palomar et al. (2017) did not find CCHFV specific IgG antibodies in 228 serum samples of humans that had reported to have regular contact with ticks. The study that Monsalve‐Arteaga et al.…”

Section: Resultsmentioning

confidence: 95%

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

Frías

Cuadrado‐Matías

Jarilla‐Fernandez

et al. 2022

Transbounding Emerging Dis

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“…Thereafter, outbreaks and further cases of CCHF were reported in wide areas in countries in Africa (Uganda, South Africa, Sudan, and Mauritania), the Middle East (Iraq, United Arab Emirates, Iran, Oman, and Saudi Arabia), Europe (Bulgaria, Kosovo, Turkey, and Albania), and Asia (China, Pakistan, Afghanistan, and India) (Ergonul 2006). Serological evidence for CCHFV further suggested the potential prevalence of this virus in a wider geographic distribution including Malaysian, Nigeria, Tunisia, Sub-Saharan Africa, Iberian Peninsula (Bukbuk et al 2014(Bukbuk et al , 2016Mohd Shukri et al 2015;Muianga et al 2017;Palomar et al 2017;Wasfi et al 2016). Hence, CCHFV may be more widely distributed worldwide than is currently known.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China

et al. 2018

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Crimean-Congo hemorrhagic fever (CCHF) caused by the CCHF virus (CCHFV) is a tick-borne natural focal disease with a mortality rate of approximately 50%. CCHFV is widely prevalent in Africa, southern Asia, the Middle East, and southeast Europe. CCHF outbreaks have been reported previously in Xinjiang province, China, especially in its southern region. Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks, rodents, and infected individuals from cities and counties in southern Xinjiang. Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype, based on complete sequences of the S segments of its negative-stranded RNA genome. The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang. Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses; these analyses indicated that the genotype of both strains was different from that of other Chinese strains. Furthermore, previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed. CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years, and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains. Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains.

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“…In certain areas of Spain (Palomar et al . 2017) and the Sulaimani Province of Iraq (Aziz et al . 2016), a collaborative diagnosis approach involving PCR and indirect immunofluorescence for specific IgG antibodies was used for CCHF virus surveillance in collected ticks.…”

Section: Tick‐borne Encephalitis Virusmentioning

confidence: 99%

Tick‐borne viruses: Current trends in large‐scale viral surveillance

Park

Kim

et al. 2020

Entomological Research

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Ticks are ectoparasites that transmit pathogens, such as tick‐borne viruses, to their hosts. Tick‐borne viruses are diverse: they can be categorized into two orders, nine families, and at least 12 genera. Almost 25% of these viruses are infectious to humans and some are a serious threat to public health. The global rise in tick‐borne virus diseases has been linked to climate change which has reduced tick mortality in the winter and extended their active period. The spread of tick‐borne viral diseases to humans has received significant interest due to the increased threat to human life; epidemiological monitoring of tick‐borne viruses using molecular, immunological, and environmental methods is now a priority. Nevertheless, many tick‐borne diseases remain undiagnosed, which poses a challenge to public administration and health care officials. This review discusses three major tick‐borne RNA viruses that cause serious infection in humans: severe fever with thrombocytopenia syndrome (SFTS) virus, tick‐borne encephalitis (TBE), and Crimean–Congo hemorrhagic fever (CCHF) virus. Specifically, we discuss the epidemiological monitoring, vector control measures, molecular diagnostics, vaccines, and environmental determinants related to these viruses. Furthermore, we review the current surveillance of these tick‐borne viruses with a specific focus on diagnostic approaches that employ molecular interventions such as viral nucleic acid isolation, PCR‐based diagnostics, and high‐throughput sequencing technologies.

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Molecular (ticks) and serological (humans) study of Crimean-Congo hemorrhagic fever virus in the Iberian Peninsula, 2013–2015

Cited by 4 publications

References 16 publications

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China

Tick‐borne viruses: Current trends in large‐scale viral surveillance

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