2021
DOI: 10.1038/s41598-021-99475-7
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Molecular testing and analysis of disease spreading during the emergence of COVID-19 in Macaé, the Brazilian National Capital of Oil

Abstract: The Brazilian strategy to overcome the spread of COVID-19 has been particularly criticized due to the lack of a national coordinating effort and an appropriate testing program. Here, a successful approach to control the spread of COVID-19 transmission is described by the engagement of public (university and governance) and private sectors (hospitals and oil companies) in Macaé, state of Rio de Janeiro, Brazil, a city known as the National Oil Capital. In 2020 between the 17th and 38th epidemiological week, ove… Show more

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Cited by 5 publications
(6 citation statements)
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“…Age had the strongest effect on the positive rate, with a 5-year-old having half the odds ratio of having a positive SARS-CoV-2 test of a 69-year-old individual. Although unclear why, this enrichment in positive test results with age among those experiencing COVID-19 compatible symptoms has been reported in other Brazilian states [ 49 , 50 ]. While older individuals are known to be more susceptible to both SARS-CoV-2 infection and COVID-19 symptoms [ 12 ], in order to explain the result it is necessary to assume that sampled symptomatic younger individuals were carriers of unknown respiratory pathogens with similar clinical outcomes, which would be circulating during the autumn and winter months of the study period (e.g., influenza, respiratory syncytial viruses).…”
Section: Discussionsupporting
confidence: 54%
“…Age had the strongest effect on the positive rate, with a 5-year-old having half the odds ratio of having a positive SARS-CoV-2 test of a 69-year-old individual. Although unclear why, this enrichment in positive test results with age among those experiencing COVID-19 compatible symptoms has been reported in other Brazilian states [ 49 , 50 ]. While older individuals are known to be more susceptible to both SARS-CoV-2 infection and COVID-19 symptoms [ 12 ], in order to explain the result it is necessary to assume that sampled symptomatic younger individuals were carriers of unknown respiratory pathogens with similar clinical outcomes, which would be circulating during the autumn and winter months of the study period (e.g., influenza, respiratory syncytial viruses).…”
Section: Discussionsupporting
confidence: 54%
“…Each sequenced sample was mapped into the municipality of Macaé using R 3.6.1. The Google Maps API was adopted from the R software package ggmap for geocoding as previously described [ 30 ], and samples were plotted every month (between April and August 2020).…”
Section: Methodsmentioning
confidence: 99%
“…Previously, our group provided detailed results of the SARS-CoV-2 distribution in Macaé and identified that COVID-19 cases in this city were male-biased, likely due to the prevalence of men as offshore workers [ 30 ]. Such studies of COVID-19 distribution in a local context are essential for understanding its macro effects on a specific region, enabling better decision-making for public health [ 30 , 31 , 32 , 33 ].…”
Section: Introductionmentioning
confidence: 99%
“…Some studies have presented evidence that antibody response may be different in children, adolescents, and adults, which potentially influences the clinical manifestations ( Weisberg et al, 2020 ). However, the causes of differential severity between ages remain unclear, presumably due to differences in the elicited immune responses ( Feitosa et al, 2021 ). Furthermore, gender is an important factor to be analyzed.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, gender is an important factor to be analyzed. Males are over-represented among patients with severe disease ( Wu & McGoogan, 2020 ; Feitosa et al, 2021 ). Finally, studies focusing on viral kinetics and antibody responses during the period of infection, as well as on the monitoring of COVID-19 patients for longer periods, are limited in the literature ( To et al, 2020 ; Takahashi et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%