Molecular targets of selenium in prostate cancer prevention (Review)

Abdulah, Rizky; Kobayashi, Kenji; Yamazaki, Chiho; Koyama, Hiroshi

doi:10.3892/ijo.2011.1035

Cited by 7 publications

(5 citation statements)

References 73 publications

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“…However, there is a wealth of preclinical data demonstrating that different chemical forms of Se have different effects. In cultured prostate cancer cells, different Se compounds target different molecular mechanisms to inhibit proliferation and viability (15,16). In rodent models of prostate cancer, various Se species likewise show varying degrees of efficacy (reviewed in ref.…”

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confidence: 99%

Selenium and Prostate Cancer Prevention: What Next—If Anything?

Christensen

2014

Cancer Prevention Research

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Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement will decrease prostate cancer risk, but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential.

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confidence: 99%

Selenium and Prostate Cancer Prevention: What Next—If Anything?

Christensen

2014

Cancer Prevention Research

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“…[10] Briefl y, cells (2 × 10 4 in 50 l/well) were plated in 96-well plates. After the initial cell seeding, different concentrations of each extract were added and incubated for 24 h. Ten microliters of water-soluble tetrazolium (WST)-8 assay cell-counting solution (Dojindo Lab., Tokyo, Japan) was added to each well and incubated at 37°C for 3 h. After the addition of 100 l/well of 1 NHCl, the cell proliferation rate was then determined by measuring the absorbance at a wavelength of 450 nm, with a reference wavelength of 650 nm.…”

Section: Drug Sensitivity Assaymentioning

confidence: 99%

Anticancer properties of daily-consumed vegetables Amaranthus spinosus, Ipomoea aquatica, Apium graveolens, and Manihot utilisima to LNCaP prostate cancer cell lines

Abdulah¹,

Diantini²,

Lusiana³

et al. 2013

J Nat Pharm

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Introduction: Prostate cancer is the second most common cancer in men worldwide. Efforts on fi nding potential sources from daily consumed foods that inhibit prostate cancer development are becoming important objective for scientists. Previous epidemiologic studies have consistently shown that consumption of fruit and vegetables was found to have signifi cant contribution in the prevention of cancer. Thus in this study, we investigated the anticancer potency of popular vegetables consumed in Indonesia, namely, Amaranthus spinosus, Ipomoea aquatica Forsk., Apium graveolens L., and Manihot utilisima to Lymph Node Carcinoma of the Prostate (LNCaP) human prostate cancer cell lines. Materials and Methods: The extracts were tested for Brine shrimp lethality test to guide their cytotoxic potencies, and methyl thiazolyl tetrazolium assay to LNCaP cells for their anticancer properties. Results: The results showed that I. aquatica Forsk has the most potential anticancer sources, with LC 50 against Artemia salina and Inhibition Concentation (IC) 50 against LNCaP being 266 g/mL and 400 g/mL, respectively. Conclusions: Our preliminary result suggest that I. aquatica Forsk. has the potential to be further investigated and developed as anticancer sources.

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“…Se induces cellular apoptosis, presumably by acting on the functions of many intracellular proteins important for these apoptotic cascades. In addition, depending on the form, Se compounds can target separate pathways and the existence of diverse responses for the same chemical structure suggest several mechanisms of action and targets [79]. In an experiment comparing the apoptotic mechanisms of the Se compounds MeSeCys, SeMet and sodium selenite in four cell lines from human oral squamous cell carcinoma (HSC-3 and HSC-4), human non-small cell lung adenocarcinoma (A549) and human breast cancer (MCF-7), showed a different response based on the both the compound and the cell line used.…”

Section: Apoptosis and Miscellaneous Mechanisms And Structuresmentioning

confidence: 99%

Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

Sanmartín

Plano

Sharma

et al. 2012

IJMS

224

170

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Selenium (Se) is an essential trace element involved in different physiological functions of the human body and plays a role in cancer prevention and treatment. Induction of apoptosis is considered an important cellular event that can account for the cancer preventive effects of Se. The mechanisms of Se-induced apoptosis are associated with the chemical forms of Se and their metabolism as well as the type of cancer studied. So, some selenocompounds, such as SeO2 involve the activation of caspase-3 while sodium selenite induces apoptosis in the absence of the activation of caspases. Modulation of mitochondrial functions has been reported to play a key role in the regulation of apoptosis and also to be one of the targets of Se compounds. Other mechanisms for apoptosis induction are the modulation of glutathione and reactive oxygen species levels, which may function as intracellular messengers to regulate signaling pathways, or the regulation of kinase, among others. Emerging evidence indicates the overlaps between the apoptosis and other types of cell death such as autophagy. In this review we report different processes of cell death induced by Se compounds in cancer treatment and prevention.

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Molecular targets of selenium in prostate cancer prevention (Review)

Cited by 7 publications

References 73 publications

Selenium and Prostate Cancer Prevention: What Next—If Anything?

Selenium and Prostate Cancer Prevention: What Next—If Anything?

Anticancer properties of daily-consumed vegetables Amaranthus spinosus, Ipomoea aquatica, Apium graveolens, and Manihot utilisima to LNCaP prostate cancer cell lines

Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

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