Molecular Targets of Neurotoxic Insecticides in <i>Apis mellifera</i>

Cens, Thierry; Chavanieu, Alain; Bertaud, Anaïs; Mokrane, Nawfel; Estaran, Sébastien; Roussel, Julien; Ménard, Claudine; Ferreira, Marie-Céleste de Jesus; Guiramand, Janique; Thibaud, Jean‐Baptiste; Cohen-Solal, Catherine; Rousset, Matthieu; Rolland, Valérie; Vignes, Michel; Charnet, Pierre

doi:10.1002/ejoc.202101531

Cited by 7 publications

(3 citation statements)

References 159 publications

(303 reference statements)

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“…2) Sodium channel blocker insecticides (SCBIs) are a relatively new group of pesticides exemplified by metaflumizone and indoxacarb, which are commercially registered chemicals. It is well-known that SCBIs like pyrethroids and DDT intoxicate insects by blocking their access to voltage-gated sodium channels (VGSCs) ( Cens et al, 2022 ). The sodium channel in nerve cells is disrupted by KDR (knockdown resistance).…”

Section: Resistance In Invasive Insectsmentioning

confidence: 99%

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

et al. 2023

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Threatening the global community is a wide variety of potential threats, most notably invasive pest species. Invasive pest species are non-native organisms that humans have either accidentally or intentionally spread to new regions. One of the most effective and first lines of control strategies for controlling pests is the application of insecticides. These toxic chemicals are employed to get rid of pests, but they pose great risks to people, animals, and plants. Pesticides are heavily used in managing invasive pests in the current era. Due to the overuse of synthetic chemicals, numerous invasive species have already developed resistance. The resistance development is the main reason for the failure to manage the invasive species. Developing pesticide resistance management techniques necessitates a thorough understanding of the mechanisms through which insects acquire insecticide resistance. Insects use a variety of behavioral, biochemical, physiological, genetic, and metabolic methods to deal with toxic chemicals, which can lead to resistance through continuous overexpression of detoxifying enzymes. An overabundance of enzymes causes metabolic resistance, detoxifying pesticides and rendering them ineffective against pests. A key factor in the development of metabolic resistance is the amplification of certain metabolic enzymes, specifically esterases, Glutathione S-transferase, Cytochromes p450 monooxygenase, and hydrolyses. Additionally, insect guts offer unique habitats for microbial colonization, and gut bacteria may serve their hosts a variety of useful services. Most importantly, the detoxification of insecticides leads to resistance development. The complete knowledge of invasive pest species and their mechanisms of resistance development could be very helpful in coping with the challenges and effectively developing effective strategies for the control of invasive species. Integrated Pest Management is particularly effective at lowering the risk of chemical and environmental contaminants and the resulting health issues, and it may also offer the most effective ways to control insect pests.

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Section: Resistance In Invasive Insectsmentioning

confidence: 99%

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

et al. 2023

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“…Investigations into isoxazoline insecticides started around the year 2000 by researchers from Nissan, which led to the isoxazoline lead 1, shown in Fig. 1, thus enabling the development of an important new class of insecticides 44 . Due to their structural aspects, the principal functional unit of these preparations is the 3 and 5‐disubstituted isoxazoline 43,45 .…”

Section: Introductionmentioning

confidence: 99%

“…1, thus enabling the development of an important new class of insecticides. 44 Due to their structural aspects, the principal functional unit of these preparations is the 3 and 5-disubstituted isoxazoline. 43,45 Some examples of commercial isoxazoline insecticides are listed in Fig.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis, characterization, and biochemical impacts of new bioactive isoxazoline‐sulfonamides as potential insecticidal agents against the Sphodroxia maroccana Ley

Mahmoudi

Fegrouche

Tachallait

et al. 2023

Pest Management Science

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BACKGROUNDSphodroxia maroccana Ley is a pest of cork oak crops that damages the roots of seedlings and can severely impair cork oak regeneration. Since the banning of carbosulfan and chlorpyriphos, which were widely used against the larvae of Sphodroxia maroccana because of their harmful impact on the environment, until now there has been no pesticide against these pests. Therefore, it is particularly urgent to develop highly effective insecticidal molecules with novel scaffolds. Isoxazolines are a class of insecticides that act on γ‐aminobutyric acid (GABA)‐gated chloride channel allosteric modulators. In this work, a green synthesis of novel 3,5‐disubstituted isoxazoline‐sulfonamide derivatives was achieved in water via ultrasound‐assisted four‐component reactions, and their insecticidal activities against fourth‐instar larvae of S. maroccana were evaluated.RESULTSMost of the tested compounds showed insecticidal activity compared to fluralaner as positive control and commercially available insecticide. Especially, the isoxazoline‐secondary sulfonamides containing halogens (Br and Cl) on the phenyl group attached to the isoxazoline, 6g (LC50 = 0.31 mg/mL), 6j (LC50 = 0.38 mg/mL), 6k (LC50 = 0.18 mg/mL), 6L (LC50 = 0.49 mg/mL), 6m (LC50 = 0.24 mg/mL), 6q (LC50 = 0.46 mg/mL), exhibited much higher larvicidal activity than fluralaner (LC50 = 0.99 mg/mL).CONCLUSIONNovel isoxazolines containing sulfonamide moieties were designed, synthesized and confirmed by two single‐crystal structures of 4e and 6q. Their bioassay results showed significant larvicidal activity with significant morphological changes in vivo. These results will lay the foundation for the further discovery and development of isoxazoline‐sulfonamide derivatives as novel crop protection larvicides of cork oak. © 2023 Society of Chemical Industry.

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Understanding role of pesticides in development of Parkinson's disease: Insights from Drosophila and rodent models

Afsheen,

Rehman,

Jamal

et al. 2024

Ageing Research Reviews

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Molecular Targets of Neurotoxic Insecticides in Apis mellifera

Cited by 7 publications

References 159 publications

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

Green synthesis, characterization, and biochemical impacts of new bioactive isoxazoline‐sulfonamides as potential insecticidal agents against the Sphodroxia maroccana Ley

Understanding role of pesticides in development of Parkinson's disease: Insights from Drosophila and rodent models

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