Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents

Synthesis and Anticonvulsant Activity of 1-Substituted-7-Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline

“…1) Since the anticonvulsant agents currently used in the treatment of epilepsy have certain disadvantages such as notable side effects and inefficient therapy in some seizure types, a clear need for safer and more effective antiepileptic drugs is well known. [1][2][3] Therefore the development of new antiepileptic drugs with approved therapeutic properties is an important challenge for medicinal chemists.…”

Crystal structure of 2,3-diphenyl-1-(morpholin-4-ylacetyl)-1,3-diazaspiro[4.5]decan-4-one, C26H31N3O3

“…Nevertheless, approximately 30% of the patients don't repay to the available antiepileptic medications [3]. In addition, long term administration of the currently used antiepileptics is accompanied by unfavourable side effects like megaloblastic anaemia and hepatotoxicity [4,5]. Accordingly, the search for new antiepileptic agents endowed with high potency and better safety profile has gained a considerable attention.…”

Crystal structure of 2,3-diphenyl-1-[(dipropylamino)acetyl]-1,3-diazaspiro[4.5]decan-4-one, C28H37N3O2

“…Many new antiepileptic drugs have been introduced in the market, however the available antiepileptics fail to prevent the seizures in approximately 30% of patients [6]. Moreover, these medications are associated with severe adverse effects such as gingival hyperplasia, megaloblastic anaemia and hepatotoxicity [7,8]. Therefore, there is a great need for the development of new, more effective and less toxic antiepileptic agents.…”