Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
De-Yi Geng,
Qing-Shan Chen,
Wan-Xian Chen
et al.
Abstract:Metastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target s… Show more
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