Abstract:There is an urgent need for new in vitro methods to predict the potential developmental toxicity of candidate drugs in the early lead identification and optimisation process. This would lead to a reduction in the total number of animals required in full-scale developmental toxicology studies, and would improve the efficiency of drug development. However, suitable in vitro systems permitting robust high-throughput screening for this purpose, for the most part, remain to be designed. An understanding of the mech… Show more
“…Article 35 (1), 61-70. Jergil, M.seeStigson, M. et al (2007). Molecular targets and early response biomarkers for the prediction of developmental toxicity in vitro.…”
“…Article 35 (1), 61-70. Jergil, M.seeStigson, M. et al (2007). Molecular targets and early response biomarkers for the prediction of developmental toxicity in vitro.…”
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