Molecular Subtypes of Breast Cancer

Abstract

Breast cancer is a public health issue especially in developing countries where morbidity and mortality are rising.as against developed countries, it is an aggressive disease in developing countries. Breast cancer is not one disease but a heterogenous disease with different molecular subtypes, each one exhibiting different clinical course and outcome. These different subtypes are identied by immunohistochemistry, each with its different method of management. The purpose of this study is to determine the frequency of the different subtypes in our Breast cancer patients. AIMS AND OBJECTIVES 1. To determine the molecular subtypes 2. To determine the frequency of each subtype. METHODS Consecutive patients diagnosed with Breast Cancer were recruited in this prospective study. Specimens were taken through core biopsy or Fine Needle Aspiration. Informed consent was taken. The vital data of each patient, including age, sex, height, weight, and examination ndings, were entered into questionnaires. Specimens were xed in formalin. Using H & E staining, blocks were made and subjected to immunohistochemistry evaluation. RESULT We had 109 respondents, 1 male and 108 females. Age range was 23-80 (mean 50 ± 11.31). Of the 109 respondents, 49/109 (44.9%) had Hormone (ER/PR) Receptor positive and Her-2 Negative cancers. Eight (7.3%) of respondents had Her-2 enriched type of Breast cancer. The most common in this study is triple negative/Basal type which accounted for 52(47.7%). The proportion of ER positive patients was 44(40.4%) while that of PR positive was 49(44.95%). CONCLUSION A high proportion of our patients had triple negative subtype. This has a bad prognosis and patients will benet from Chemotherapy