Molecular Studies of the Effects of the Antiviral Drug, Oseltamivir (Tamiflu), on the Dna of the Testes’ Cells and the Leucocytes of the Male Adult Albino Rats

El-Ganzuri, Monir A.; El-Nabi, Sobhi Hassab; Saafan, Nazek K.; Abdel-Ghaffar, Wafaa H.

doi:10.12816/0027822

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“…The optical density gradually increased depending on the doses accumulation as well as long duration. El-Ganzuri et al [ 12 ] and Abdel-Ghaffar [ 13 ] reported that the therapeutic dose, short-term and long-term prophylactic doses gave necrotic DNA smears, but the intensity of such dose was both time- and dose-dependent.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological effects of Tamiflu on liver and kidneys of male rats

Abdel-Ghaffar

Abdelghffar

2022

Beni-Suef Univ J Basic Appl Sci

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Background Tamiflu/oseltamivir phosphate (OP), an anti-influenza drug, has a highly doubted safety especially after many cases of abnormal behaviour and deaths reported after being used. Such controversy was also locally and globally generated, especially after being heavily used in COVID-19 treatment protocol. This study was designed to evaluate the effect of three different doses of OP on the liver and kidneys of male adult albino rats through histological approaches, measuring their DNA integrity and biochemical analyses. Different doses of Tamiflu applied to humans were converted to rats, then observed their effects on the liver and kidneys. Rats were divided into four groups. G1: considered as control group. The rest of the three treated groups were received the same calculated dose of Tamiflu (6.75 mg/kg b.w.) in three different durations. G2, G3 and G4 represented the animals orally received OP, in which the rats received OP twice for 5 consecutive days, once for 10 and 45 days, respectively. Results Our data showed numerous deleterious necrotic and fibrotic histopathological changes in the liver, and kidneys; as well as necrotic DNA smears, by using electrophoresis, in OP-treated rats of G2 and G4. In addition, OP significantly increased the serum cellular hepatic/renal toxicity markers (ALT, AST, ALP, GGT, indirect bilirubin, urea, creatinine, uric acid, & Na+). Also, it showed a reduction in the levels of serum total protein, albumin and K+ ions in rats of G2 and G4 compared with G1. In G3, OP treatment did not significantly alter hepatic/renal histological, DNA integrity and biochemical analyses in rats. Conclusions The therapeutic and long-term prophylactic doses of OP most likely cause structural and functional hepato- and nephrotoxicity in experimentally subjected rats. So, caution must be taken during Tamiflu treatment, and not used for long durations and/or with repetitive doses (time- and/or accumulative-dose-dependent); especially with patients suffer from liver and/or kidney dysfunction, while the short-term prophylactic dose of OP appears to be relatively safe and could be explored for oral medications. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%