Molecular Studies of Japanese Patients With Group A Xeroderma Pigmentosum Using Polymerase Chain Reaction and Restriction Fragment Length Polymorphism and Nonradioactive Single Strand Conformation Polymorphism Analyses
Abstract:Xeroderma pigmentosum is an autosomal recessive disease characterized by extreme sensitivity of the skin to ultraviolet light, which results in a high incidence of early skin cancer. We report here the molecular analysis of the xeroderma pigmentosum group A complementing genes of five Japanese patients with group A xeroderma pigmentosum and their families, by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis, and by PCR and non-radioactive single strand conformation p… Show more
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