Molecular Structure of Human Transferrin – Transferrin Receptor Complex

Abstract

Transferrin receptor (TfR) is a glycoprotein mediating the entry of ferric transferrin (Tf) from the extracellular compartment into the cells. TfR are present on the surface of many cell types but they are most abundant on cells active in hemoglobin synthesis. However, the knowledge on the complex, recombination, between Tf and sTfR is limited. Here, the author performs an analysis to study the molecular structure of human Tf -sTfR complex. The output 3D molecular structure from the combination between Tf and TfR is derived. The property as well as geometry of the derived complex was also presented.