2018
DOI: 10.1073/pnas.1719407115
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Molecular structural diversity of mitochondrial cardiolipins

Abstract: SignificanceCardiolipins are a unique class of phospholipids in mitochondrial membranes that are crucial for cellular bioenergetics as they stabilize respiratory chain complexes. In contrast to most other phospholipids, cardiolipins are substituted with four, rather than only two fatty acyl side chains. Consequently, this opens up a vast number of different theoretically possible molecular lipid species. Experimentally assessing the molecular diversity of cardiolipin species is analytically challenging. In thi… Show more

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Cited by 85 publications
(132 citation statements)
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References 33 publications
(43 reference statements)
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“…For example, ClsA colocalizes with its cardiolipin products (Romantsov et al ., ). In the same way, cardiolipins are closely associated with cristae in mitochondria (Ikon and Ryan, ; Schlame and Greenberg, ; Oemer et al ., ). These molecules can act as seeds to induce local curvature in an autocatalytic way.…”
Section: An Open List Of Basic Cellular Maxwell's Demonsmentioning
confidence: 97%
“…For example, ClsA colocalizes with its cardiolipin products (Romantsov et al ., ). In the same way, cardiolipins are closely associated with cristae in mitochondria (Ikon and Ryan, ; Schlame and Greenberg, ; Oemer et al ., ). These molecules can act as seeds to induce local curvature in an autocatalytic way.…”
Section: An Open List Of Basic Cellular Maxwell's Demonsmentioning
confidence: 97%
“…This unveils the existence of distinct CL content thresholds to achieve complementary roles of CL in ATP production. The two last steps of CL synthesis occur within mitochondria, first CL synthase catalyses binding of CDP-diacylglycerol to phosphatidylglycerol to form CL, and then Tafazzin remodels the acylchain composition in the heart and skeletal muscles, which results in an enrichment of linoleoyl chains (C18:2, ω-6) in CL (Oemer et al, 2018). The functional importance of the latter reaction is illustrated by Barth syndrome, characterized by a life-threatening infantile dilated cardiomyopathy, which develops associated with Tafazzin deficiency (Barth et al, 1983;Ikon and Ryan, 2017a).…”
Section: Discussionmentioning
confidence: 99%
“…The PC/PE analysis was performed as described in 33 , with the modifications described in 13 . 10 µl of the samples were injected by a Dionex Ultimate 3000 HPLC (Thermofisher Scientific Inc, Waltham, USA) with a flowrate of 0.4 ml/min and a column oven temperature of 50 °C.…”
Section: Lc-ms/ms Analysismentioning
confidence: 99%