Molecular SPECT Imaging: An Overview

Khalil, Magdy M.; Tremoleda, Jordi L.; Bayomy, T.; Gsell, Willy

doi:10.1155/2011/796025

Cited by 221 publications

(152 citation statements)

References 74 publications

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“…Table 2 summarizes the main system specifications. A complete description of all the available preclinical hybrid systems is outside the focus of this review paper, please see [46,[61][62][63][64][65] for details.…”

Section: Preclinical Hybrid Imagingmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Preclinical Hybrid Imagingmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…For scatter correction, once scatter information is given with or without the aid of anatomical information, then scatter correction can be performed by subtracting the scatter information from the projection data [30,69] or by incorporating it in the statistical model (2) so that the EM algorithm becomes as follows:…”

Section: Anatomical Information For Attenuation/scatter Correction Mamentioning

confidence: 99%

“…Nuclear medicine imaging such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) is an important tool for providing valuable molecular information about patients to clinicians [1,2]. However, it is challenging to obtain good-quality images of PET and SPECT due to highly noisy measurements and various artifacts.…”

Section: Introductionmentioning

confidence: 99%

The Use of Anatomical Information for Molecular Image Reconstruction Algorithms: Attenuation/Scatter Correction, Motion Compensation, and Noise Reduction

Chun

2016

Nucl Med Mol Imaging

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PET and SPECT are important tools for providing valuable molecular information about patients to clinicians. Advances in nuclear medicine hardware technologies and statistical image reconstruction algorithms enabled significantly improved image quality. Sequentially or simultaneously acquired anatomical images such as CT and MRI from hybrid scanners are also important ingredients for improving the image quality of PET or SPECT further. High-quality anatomical information has been used and investigated for attenuation and scatter corrections, motion compensation, and noise reduction via post-reconstruction filtering and regularization in inverse problems. In this article, we will review works using anatomical information for molecular image reconstruction algorithms for better image quality by describing mathematical models, discussing sources of anatomical information for different cases, and showing some examples.

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“…Common imaging technologies used in animal biodistribution studies include optical imaging with luminescence and fluorescence molecular probes, radiotracer-based single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging, magnetic resonance imaging (MRI), ultrasound imaging, and X-ray imaging (40,41). In contrast to the conventional cut-and-count approach or wholebody autoradiography with radiolabeled biologics, imaging studies can be conducted in live animals, which provides the advantage of obtaining real-time dynamics on the biodistribution of a test article from the same animal.…”

Section: Non-invasive Imaging Technologies For Biodistribution and Pkmentioning

confidence: 99%

Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics

Vugmeyster

2012

AAPS J

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Abstract. With the advancement of biotechnology in the last two decades, optimized and novel modalities and platforms of biologic moieties have emerged rapidly in drug discovery pipelines. In addition, new technologies for delivering therapeutic biologics (e.g., needle-free devices, nanoparticle complexes), as well as novel approaches for disease treatments (e.g., stem cell therapy, individualized medicine), continue to be developed. While pharmacokinetic studies are routinely carried out for therapeutic biologics, experiments that elucidate underlying mechanisms for clearance and biodistribution or identify key factors that govern absorption, distribution, metabolism, and excretion (ADME) of biologics often are not thoroughly conducted. Realizing the importance of biologics as therapeutic agents, pharmaceutical industry has recently begun to move the research focus from small molecules only to a blended portfolio consisting of both small molecules and biologics. This trend brings many opportunities for scientists working in the drug disposition research field. In anticipation of these opportunities and associated challenges, this review highlights impact of ADME studies on clinical and commercial success of biologics, with a particular focus on emerging applications and technologies and linkage with mechanistic pharmacokinetic/pharmacodynamic modeling and biomarker research.

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Molecular SPECT Imaging: An Overview

Cited by 221 publications

References 74 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

The Use of Anatomical Information for Molecular Image Reconstruction Algorithms: Attenuation/Scatter Correction, Motion Compensation, and Noise Reduction

Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics

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