Molecular, Spatial, and Field Epidemiology Suggesting TB Transmission in Community, Not Hospital, Gaborone, Botswana

Genomic approaches to tuberculosis management and control

“…Contacts are commonly investigated in high and middle-income countries with low TB burden and transmission [31]; in those settings good results can be obtained in identifying positive contacts, likely because household transmission is predominant. On the contrary, in high TB burden areas where transmission is rampant [32,33], but also in low-incidence settings with elevated transmission, contact investigations failed to quantify transmission properly. In those settings non household-based or community transmission is prevalent and hard to capture by contact investigations [22].…”