2022
DOI: 10.1016/j.neuron.2022.06.021
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Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s disease

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Cited by 83 publications
(97 citation statements)
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References 140 publications
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“…Leng et al [ 45 ] showed that RORB+ glutamatergic neurons are selectively depleted in the entorhinal cortex, but not in the superior frontal gyrus, evidence for layer- and subset-specific early-stage neurodegeneration in AD. Similarly, Otero-Garcia et al [ 43 ] used a novel partial cell body sorting technique to identify that a subset of neurons in layer 2/3, as well as a subset of deeper layer RORB+-positive neurons in the frontal cortex, are enriched among cells with higher abundance of intracellular AT8+ tau in their somata. In addition, these vulnerable sets of neurons share a common upregulation of genes encoding for synaptic and cytoskeletal proteins [ 43 ], as has been found in other snRNA-seq studies [ 40 , 44 ].…”
Section: Neuronal Subtypes Show Selective Vulnerability To Tau and Ne...mentioning
confidence: 99%
See 2 more Smart Citations
“…Leng et al [ 45 ] showed that RORB+ glutamatergic neurons are selectively depleted in the entorhinal cortex, but not in the superior frontal gyrus, evidence for layer- and subset-specific early-stage neurodegeneration in AD. Similarly, Otero-Garcia et al [ 43 ] used a novel partial cell body sorting technique to identify that a subset of neurons in layer 2/3, as well as a subset of deeper layer RORB+-positive neurons in the frontal cortex, are enriched among cells with higher abundance of intracellular AT8+ tau in their somata. In addition, these vulnerable sets of neurons share a common upregulation of genes encoding for synaptic and cytoskeletal proteins [ 43 ], as has been found in other snRNA-seq studies [ 40 , 44 ].…”
Section: Neuronal Subtypes Show Selective Vulnerability To Tau and Ne...mentioning
confidence: 99%
“…Similarly, Otero-Garcia et al [ 43 ] used a novel partial cell body sorting technique to identify that a subset of neurons in layer 2/3, as well as a subset of deeper layer RORB+-positive neurons in the frontal cortex, are enriched among cells with higher abundance of intracellular AT8+ tau in their somata. In addition, these vulnerable sets of neurons share a common upregulation of genes encoding for synaptic and cytoskeletal proteins [ 43 ], as has been found in other snRNA-seq studies [ 40 , 44 ]. This study also identified certain RORB+ neuronal subsets as being resistant to the accumulation of tau pathology, whereas the RORB+/PCP4+ subgroup preferentially accumulates tau; this suggests that not all projection neurons, even within the same cortical layer, are equally vulnerable.…”
Section: Neuronal Subtypes Show Selective Vulnerability To Tau and Ne...mentioning
confidence: 99%
See 1 more Smart Citation
“…On the other hand, many neurodegenerative diseases are thought to be driven by the toxic aggregation of specific proteins; therefore, a reduction in the level of those proteins may be therapeutically beneficial. Furthermore, the accumulation of toxic protein aggregates or other pathological products in a cell could be associated with disease-associated cell states [68,69]. Several genetic screens have uncovered positive and negative regulators of the levels of disease-relevant proteins.…”
Section: Modifiers Of Levels Of Disease-relevant Proteinsmentioning
confidence: 99%
“…Converging with these insights, single-cell sequencing of mouse models of AD has uncovered disease-associated microglia (DAM) [4][5][6] and astrocytes (DAA) [7]; both DAM and DAA appear to be driven by amyloid pathology. Beyond mouse models, single-cell profiling of human AD brain tissue has identified a variety of disease-associated perturbations in neurons as well as glia [5,[8][9][10][11][12][13][14][15]. It is likely that in human AD, multiple disease-associated microglial states exist [9,11], which may partially explain the limited overlap of DAM markers with upregulated genes in microglia found in human AD brain tissue [5].…”
mentioning
confidence: 99%