Molecular signatures of secretomes from mesenchymal stem cells: therapeutic benefits

Suh, Nayoung; Subramanyam, Deepa; Lee, Mi-Young

doi:10.1007/s13273-017-0014-9

Cited by 9 publications

(5 citation statements)

References 76 publications

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“…Having established the definition of exosomes as nanoscopic particles derived from MSCs, one might conclude that they are, in effect, the mediators of MSC functions in a paracrine fashion [ 96 ]. Similar to other exosomes, MSCs-derived exosomes transport a complex cargo of lipids, proteins, and nucleic acids.…”

Section: Msc-derived Exosome Characteristicsmentioning

confidence: 99%

The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

et al. 2022

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Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more pathology-oriented therapeutic approach. Regenerative cell therapy has provided us with an unrivalled platform for evaluating potentially effective novel methods for treating neurodegenerative illnesses over the last two decades. Mesenchymal stem cells (MSCs) are most promising, as they can differentiate into dopaminergic neurons and produce neurotrophic substances. The precise process by which stem cells repair neuronal injury is unknown, and MSC-derived exosomes are suggested to be responsible for a significant portion of such effects. The present review discusses the application of mesenchymal stem cells and MSC-derived exosomes in PD treatment.

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Section: Msc-derived Exosome Characteristicsmentioning

confidence: 99%

The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

et al. 2022

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“…Therefore, further studies are needed for elucidating the network between EVs and exosome alteration, which is implicated in CS exposure and disease progression. A wide range of EV and exosome studies depicting the diagnostic or therapeutic feasibility of them are in clinical test [ 67 , 68 ]. However, it is premature to find the links between EV and exosome alterations and CS-specific diseases.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

The Potential Roles of Extracellular Vesicles in Cigarette Smoke‐Associated Diseases

Ryu

Kim

et al. 2018

Oxidative Medicine and Cellular Longevity

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Cigarette smoke contains more than 4,500 chemicals; most of which are highly reactive free radicals, which induce proinflammatory and carcinogenic reactions. Numerous efforts have focused extensively on the role of cigarette smoking as a cause of many diseases. Extracellular vesicles and exosomes have recently received increasing interest for their diagnostic and therapeutic roles in many diseases. However, research done on the role of extracellular vesicles and exosomes on cigarette smoke-induced chronic disease is still in its infancy. In this review, we summarize the recently addressed roles of extracellular vesicles and exosomes in the pathogenesis of cigarette smoke-related diseases, such as chronic obstructive pulmonary disease, cardiovascular disease, lung cancer, and oral cancer. Moreover, their potential utilization and future prospects as diagnostic biomarkers for cigarette smoke-related diseases are described.

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“…MSCs exhibit reparative, regenerative and immunomodulatory effects through paracrine signaling to generate AKT-MSC activity and release various anti-apoptotic, mitogenic, and pro-angiogenic factors as the main mechanism for biomedical applications [ 36 , 37 ]. The role of paracrine is now considered as one of the main features for MSC secretome-mediated repair and regeneration following several in vitro and in vivo studies [ 38 ]. Various studies have shown that the MSC secretome has been successfully assessed in various pathological conditions, such as alopecia, acute and chronic wound healing, myocardial infarction, acute liver injury, cerebral and spinal cord injury, lung injury, and bone defects [ 39 ].…”

Section: Overview Of Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

“…Studies show that the efficacy of MSCs for biomedical applications is mediated by secreted factors, such as insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), transforming growth factor beta-1 (TGF-β1), basic fibroblast growth factor (bFGF), placental growth factor (PGF), nerve growth factor (NGF), interleukin-1 (IL-1), IL-6, IL-10, and Tumor Necrosis Factor alpha (TNF-α) [ 36 , 38 , 50 ]. The secretomes of different MSC populations in different tissues appear to be variable, and their composition may change in response to physiological and pathological situations [ 23 ].…”

Section: Overview Of Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications

et al. 2022

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Secretomes of mesenchymal stem cells (MSCs) have been successfully studied in preclinical models for several biomedical applications, including tissue engineering, drug delivery, and cancer therapy. Hydrogels are known to imitate a three-dimensional extracellular matrix to offer a friendly environment for stem cells; therefore, hydrogels can be used as scaffolds for tissue construction, to control the distribution of bioactive compounds in tissues, and as a secretome-producing MSC culture media. The administration of a polymeric hydrogel-based MSC secretome has been shown to overcome the fast clearance of the target tissue. In vitro studies confirm the bioactivity of the secretome encapsulated in the gel, allowing for a controlled and sustained release process. The findings reveal that the feasibility of polymeric hydrogels as MSC -secretome delivery systems had a positive influence on the pace of tissue and organ regeneration, as well as an enhanced secretome production. In this review, we discuss the widely used polymeric hydrogels and their advantages as MSC secretome delivery systems in biomedical applications.

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Molecular signatures of secretomes from mesenchymal stem cells: therapeutic benefits

Cited by 9 publications

References 76 publications

The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

The Potential Roles of Extracellular Vesicles in Cigarette Smoke‐Associated Diseases

Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications

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