Molecular Signatures for Microbe-Associated Colorectal Cancers
Ibrahim M Sayed,
Daniella T Vo,
Joshua Alcantara
et al.
Abstract:BackgroundGenetic factors and microbial imbalances play crucial roles in colorectal cancers (CRCs), yet the impact of infections on cancer initiation remains poorly understood. While bioinformatic approaches offer valuable insights, the rising incidence of CRCs creates a pressing need to precisely identify early CRC events. We constructed a network model to identify continuum states during CRC initiation spanning normal colonic tissue to pre-cancer lesions (adenomatous polyps) and examined the influence of mic… Show more
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