Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to the human brain evolution
K. Ciuba,
A. Piotrowska,
D. Chaudhury
et al.
Abstract:Astrocytes contribute to the development and regulation of the higher-level functions of the brain, the critical targets of evolution. However, the molecular signature of foetal astrocyte evolution in primates is unknown. Here, to address this question, we use human, chimpanzee, and macaque induced pluripotent stem cell-derived foetal astrocytes (iAstrocytes). Human iAstrocytes are bigger and more complex than the non-human primate iAstrocytes. We find loci related to the regulation of cell size with increased… Show more
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