Molecular signaling within growth plates of the radius and tibia after periosteal stripping: an experimental study in lambs

Rechenberg, Brigitte von; Tanner, Stuart; Hilbe, Monika; Zlinszky, K.; Kämpf, Katharina; Wedel, F. von; Kümmerle, Jan M; Picek, S.; Vogt, R.; Auer, Jörg A

doi:10.21836/pem20100401

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…In agreement with these reports, PR decreased density of metaphyseal trabecular bone in both mice models in the current study. A molecular signaling study after PR demonstrated that Indian hedgehog (IHH) was highly expressed in the hypertrophic zone of the growth plate in a lamb model ( von Rechenberg et al, 2010 ). Activated IHH signaling promoted bone formation, but the resulting bone was very fragile and porous due to severe bone resorption ( Mak et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

et al. 2020

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Achondroplasia (ACH) is the most common form of short-limbed skeletal dysplasia. Patients with ACH sometimes undergo lower limb lengthening to get functional and psychological achievements. The periosteal resection (PR) is a known mechanism to increase longitudinal bone growth without osteotomy, although the results are not predictable. It could be alternative for limb lengthening in a minimally invasive technique. The purpose of this study is to evaluate the effect of PR on acceleration of bone growth in a mouse model of ACH ( Fgfr3 ach ). We performed a circumferential resection of periosteum on the proximal tibia to both wild-type and Fgfr3 ach mice at the age of four weeks. The second PR was done one week later in each mouse, which was subsequently sacrificed at the age of six weeks for micro-computed tomography (micro-CT) scan and histological examinations. We measured tibial bone length, bone volume, and metaphyseal trabecular bone parameters, including bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N) by reconstructed micro-CT images. We also quantified the entire width of the growth plate of the proximal tibial from the sections stained with hematoxylin and eosin. Tibial bone length and bone volume of the PR side were significantly larger than the sham side in wild-type mice, while they were not statistically significant in Fgfr3 ach mice. The BV/TV and Tb.N in the metaphysis were significantly decreased in the PR side of both mice. The histological analysis revealed that the growth plate of the proximal tibia was significantly wider in the PR side of wild-type mice while it showed no difference in width between the PR side and the sham side in Fgfr3 ach mice. PR promoted longitudinal bone growth in wild-type mice, but it exhibited only a marginal effect on bone growth in Fgfr3 ach mice.

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Section: Discussionmentioning

confidence: 99%

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

et al. 2020

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“…Conversely, work on lambs has shown that periosteal transection and elevation have a direct effect on parthyroid hormone and related peptide, all of which are involved in bone growth (Von Rechenberg et al . ).…”

Section: Introductionmentioning

confidence: 97%

Single transphyseal screws for the correction of moderate to severe angular limb deformities in 28 Thoroughbred foals

Gray

Randleff-Rasmussen

Lepage

2017

Equine Veterinary Education

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Summary This study reports on the effective use of a single transphyseal screw for the treatment of moderate to severe angular limb deformities (ALDs) of the fetlocks and carpi of 28 young Thoroughbred foals. The objective was to evaluate the surgical management of foals with moderate to severe ALDs treated with single transphyseal screws. Evaluation of medical records of 28 Thoroughbred foals treated with single transphyseal screws placed across the distal radial, metacarpal and metatarsal physes was undertaken. The angle of joint deviation was measured prior to implantation and at removal of the implants, and the degree of improvement was calculated. A total of 39 screws were placed: 24 in the distal metacarpus or metatarsus and 15 in the distal radial physis. Varus or valgus deformities in the fetlock improved by 4–5° over a period of 15–30 days. Varus or valgus deformities in the carpi improved by 8–11° in 11–56 days. One case failed to improve adequately due to implant infection. Single transphyseal screws were effective in treating moderate to severe varus and valgus ALD of the fetlocks and carpi in young Thoroughbred foals. Further investigation into their use in the distal radius in young foals is needed. While single transphyseal screws are almost exclusively used by some clinics in the distal metatarsal and metacarpal physes, many clinicians do not use them in the distal radial physis of young foals due to fear of over‐correction, physitis and metaphyseal collapse. This was not observed in any of our cases.

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“…Acceleration is achieved by hemicircumferential periosteal transection and elevation, whereas retardation requires static compression of hypertrophic chondrocytes at the physis, usually by orthopedic implants such as transphyseal cortex screws or screws and wires. [11][12][13] In 2 small experimental studies, periosteal elevation was not more effective than conservative management. 14,15 Additionally, in a large retrospective cohort study, horses treated with periosteal elevation had poorer outcomes than sibling controls.…”

Section: Introductionmentioning

confidence: 99%

“…The surgical methods described for the correction of angular limb deformities are aimed at either acceleration or retardation of bone growth. Acceleration is achieved by hemicircumferential periosteal transection and elevation, whereas retardation requires static compression of hypertrophic chondrocytes at the physis, usually by orthopedic implants such as transphyseal cortex screws or screws and wires 11–13 . In 2 small experimental studies, periosteal elevation was not more effective than conservative management 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Single‐incision drilling technique to achieve hemiepiphysiodesis of the distal metacarpus – complications and outcome in 207 foals with metacarpophalangeal varus deformities

Boorman

Rodgerson

2022

Veterinary Surgery

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Objective: To report the outcome of foals treated for metacarpophalangeal varus deformity with a single-incision drilling technique for hemiepiphysiodesis of the distal lateral metacarpal physis.Study design: Retrospective case-control cohort study. Animals: Thoroughbred foals (n = 207), 171 age-and sex-matched maternal siblings. Methods: Medical records (2017-2020) were reviewed for signalment, limb(s) treated, location of the surgery, and any reported complications. Follow-up radiographs obtained for the yearling sale were assessed for abnormalities. Horses were matched to maternal siblings using an online database. Sales and racing performance data were compared between cohorts. Results: The average age at the time of surgery was 97 days. The treated limb was the left front in 52, right front in 31, both fronts in 119, unknown in 5. Three horses developed calcinosis circumscripta lesions adjacent to the physis, which were removed successfully. No radiographic abnormalities associated with the surgery site were detected on yearling prepurchase radiographs. There were no differences in sales and racing performance data between treated horses and maternal controls. Conclusion: Hemiepiphysiodesis is a safe and effective treatment for metacarpophalangeal varus deformities in foals. No negative effect on sales or racing performance was identified. Clinical significance: This technique avoids risks, costs, and the need for second surgery associated with an orthopedic implant. The surgeon should be aware of the potential for development of a calcinosis circumscripta lesion with this technique.

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Molecular signaling within growth plates of the radius and tibia after periosteal stripping: an experimental study in lambs

Cited by 6 publications

References 39 publications

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

Single transphyseal screws for the correction of moderate to severe angular limb deformities in 28 Thoroughbred foals

Single‐incision drilling technique to achieve hemiepiphysiodesis of the distal metacarpus – complications and outcome in 207 foals with metacarpophalangeal varus deformities

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